Evidence map›Paper›PMID 39835891›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Identification of

Kathryn J Bjornson, Bailey A Kermath, Michael E Cahill

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kathryn J BjornsonDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0001-5366-1230
Bailey A KermathDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706.
Michael E CahillDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-0574-2655

Funding

A multidisciplinary approach identifying PDZ-RhoGEF (ARHGEF11) as a critical regulator of synapses and cognitionR01MH133846 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI MICHAEL Edward CAHILL · 2024 to 2026
$1.1M
NIH (NIMH) R01MH1338746NIMH NIH HHS R01 MH133846
6 · The paper itself

Abstract

Given the influence of cognitive abilities on life outcomes, there is inherent value in identifying genes involved in controlling learning and memory. Further, cognitive dysfunction is a core feature of many neuropsychiatric disorders. Here, we use a combinatory in silico approach to identify human gene targets that will have an especially high likelihood of individually and directly impacting cognition. This broad and unbiased screen led to the specific identification of

Indexed as

CognitionRho Guanine Nucleotide Exchange FactorsSynapsesAnimalsDendritic SpinesHumansMiceMicroRNAsPrefrontal CortexARHGEF11 protein, humanMicroRNAsRho Guanine Nucleotide Exchange Factorscognitiondendritic spinelearningmemorymir132

Identifiers

PMID39835891
PMCPMC11789018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.