Evidence map›Paper›PMID 39835844›Full record

SynthesisJournal of clinical hypertension (Greenwich, Conn.)2025

Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis.

Ajay Malvi, Muhammed Shabil, Mahalaqua Nazli Khatib, Roopashree R, Mandeep Kaur, Manish Srivastava, Amit Barwal, G V Siva Prasad, Pranchal Rajput, Rukshar Syed and 10 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical hypertension (Greenwich, Conn.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ajay MalviDepartment of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Guwahati, India.
Muhammed ShabilNoida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India.
Mahalaqua Nazli KhatibDivision of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India.
Roopashree RDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Mandeep KaurDepartment of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, India.
Manish SrivastavaDepartment of Endocrinology, NIMS University, Jaipur, India.
Amit BarwalChandigarh Pharmacy College, Chandigarh Group of College, Jhanjeri, Mohali, Punjab, India.
G V Siva PrasadDepartment of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, India.
Pranchal RajputSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, India.
Rukshar SyedIES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, India.
Kamal KundraNew Delhi Institute of Management, Tughlakabad Institutional Area, New Delhi, India.
Vinamra MittalGraphic Era Institute of Medical Sciences, Graphic Era (Deemed to be University), Clement Town, Dehradun, India.
Amit KumarCentre of Research Impact and Outcome, Chitkara University, Rajpura, Punjab, India.
Pancham CajlaChitkara Centre for Research and Development, Chitkara University, Pinjore, Himachal Pradesh, India.
Ganesh BushiSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.
Rachana MehtaClinical Microbiology, RDC, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India.
Zaid KhanCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Prakasini SatapathyUniversity Center for Research and Development, Chandigarh University, Mohali, Punjab, India.
Shilpa GaidhaneOne Health Centre (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India.
Renu SahSR Sanjeevani Hospital, Siraha, Kalyanpur, Nepal.ORCID 0009-0002-1222-3765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex hormone-binding globulin (SHBG) regulates sex hormone availability and is influenced by metabolic factors. Variations in SHBG levels during pregnancy may affect the development of hypertensive disorders such as gestational hypertension (GH) and preeclampsia (PE). This systematic review and meta-analysis explores the potential of SHBG as a biomarker for predicting GH and PE. A search of PubMed, Embase, and Web of Science was conducted to identify studies evaluating the association between SHBG levels and the risk of HDP, including GH and PE. Inclusion criteria encompassed observational studies reporting quantitative risk estimates (risk ratios, odds ratios, or hazard ratios) for SHBG levels. Results were pooled using a random-effects meta-analysis in R software (V 4.4), with the I

Indexed as

Hypertension, Pregnancy-InducedPre-EclampsiaSex Hormone-Binding GlobulinBiomarkersFemaleHumansPregnancyRisk FactorsBiomarkersSex Hormone-Binding GlobulinSHBG protein, humangestational hypertensionhypertensive disorders of pregnancypreeclampsiapregnancy biomarkersex hormone binding globulin

Identifiers

PMID39835844
PMCPMC11771790

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.