Evidence map›Paper›PMID 39835687›Full record

ArticleClinical and translational gastroenterology2025

Healthcare Contact Days Before and After Liver Transplant in Patients With Cirrhosis: A National Cohort Study.

Hirsh Elhence, Gurmehr Brar, Jennifer L Dodge, Brian P Lee

Abstract read
In one paragraph

Article in Clinical and translational gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hirsh ElhenceDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Gurmehr BrarDepartment of Medicine, University of Southern California, Los Angeles, California, USA.
Jennifer L DodgeDepartment of Medicine, University of Southern California, Los Angeles, California, USA.
Brian P LeeDivision of Gastroenterology and Liver Diseases, University of Southern California, Los Angeles, California, USA .ORCID 0000-0003-2108-1287

Funding

USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAMM-ALVAREZ, SARAH F · 1995 to 2020
$21.8M
1/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)R01AA030960 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Norah A. Terrault · 2023 to 2026
$2.3M
Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized InterventionsK23AA029752 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, BRIAN PEI LIM · 2022 to 2025
$772k
NIAAA NIH HHS K23 AA029752NIAAA NIH HHS K23AA029752NIAAA NIH HHS R01 AA030960NIAAA NIH HHS R01AA030960NIDDK NIH HHS P30 DK048522NIDDK NIH HHS P30DK048522
6 · The paper itself

Abstract

introduction"Healthcare contact days" is a patient-centered quantitative proxy for time toxicity, which can be informative for liver transplant (LT) decision-making. We aimed to (i) quantify contact days in patients with cirrhosis pre-LT and post-LT and (ii) identify clinical and demographic features associated with contact days.

methodsUsing a national health system database, we calculated healthcare contact days (inpatient, outpatient hospital [e.g. observation], ambulatory, emergency, mental health, other) for patients with cirrhosis before and after LT.

resultsBetween 2008 and 2023, 2,708 patients underwent LT (median age 59 years [interquartile range 52-65], 66% male, 68% non-Hispanic White). Total mean contact days were 76.0 (SD, 58.6) 1 year pre-LT, increasing to 92.3 (SD, 63.2) 1 year post-LT, then decreasing to 39.7 (SD, 43.3) and 30.9 (SD, 35.6) 2 years and 3 years post-LT, respectively. The mean inpatient contact days were 33.6 (SD, 47.5) 1 year pre-LT, increasing to 49.6 (SD, 59.1) 1 year post-LT, then decreasing to 11.9 (SD, 32.0) and 6.7 (SD, 19.8) 2 years and 3 years post-LT, respectively. In multivariable analysis, pre-LT contact days were not associated with post-LT days (incidence rate ratio [IRR] 1.00 [1.00-1.00]). Post-LT, female gender (IRR 1.09 [1.03-1.15]), Black race (IRR 1.11 [1.00-1.23]), and pre-LT dialysis (IRR 1.21 [1.10-1.34]) were associated with increased total contact days. DISCUSSION: Healthcare contact days provide interpretable prognostic information to inform expectations regarding LT for cirrhosis and can be useful for patients, providers, and policymakers alike.

Indexed as

Liver CirrhosisLiver TransplantationAgedDatabases, FactualFemaleHumansMaleMiddle AgedTime FactorsUnited Statesdisparitieshealthcare utilizationliver diseaseshared decision-making

Identifiers

PMID39835687
PMCPMC12020701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.