Evidence map›Paper›PMID 39835654›Full record

Trial reportAge and ageing2025

Early detection and management of hearing loss to reduce dementia risk in older adults with mild cognitive impairment: findings from the treating auditory impairment and cognition trial (TACT).

Ruan-Ching Yu, Menelaos Pavlou, Anne G M Schilder, Doris-Eva Bamiou, Glyn Lewis, Frank Robert Lin, Gill Livingston, Danielle Proctor, Rumana Omar, Sergi G Costafreda

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Age and ageing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. [Current status and future perspectives on age-related hearing loss and cognitive impairment].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruan-Ching YuDivision of Psychiatry, University College London, London, UK.
Menelaos PavlouDepartment of Statistical Science, University College London, London WC1E 6BT, UK.
Anne G M SchilderEar Institute, University College London, London, UK.
Doris-Eva BamiouEar Institute, University College London, London, UK.
Glyn LewisDivision of Psychiatry, University College London, London, UK.
Frank Robert LinDepartment of Otolaryngology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gill LivingstonDivision of Psychiatry, University College London, London, UK.ORCID 0000-0001-6741-5516
Danielle ProctorNorth London NHS Foundation Trust, London, UK.
Rumana OmarDepartment of Statistical Science, University College London, London WC1E 6BT, UK.
Sergi G CostafredaDivision of Psychiatry, University College London, London, UK.

Funding

Alzheimer's Research UK ARUK-PRRF2017-001
6 · The paper itself

Abstract

backgroundAge-related hearing loss and mild cognitive impairment (MCI) independently increase dementia risk. The Ageing and Cognitive Health Evaluation in Elders randomised controlled trial (RCT) found hearing aids reduce cognitive decline in high-risk older adults with poor hearing.

methodsThis pilot RCT in London memory clinics randomised people with MCI (aged ≥55, untreated hearing loss defined as Pure Tone Average 0.5-4 KHz between 25-70 dB) into two groups. The intervention group received 4 sessions of hearing aid fitting and support. The control group received healthy ageing education and a GP letter recommending audiological referral. Both were followed for 6 months. Primary outcomes were recruitment (feasibility target: 50%; 95% CI: 39%-61%) and retention (feasibility target: 80%; 95% CI: 71%-89%); intervention completion (≥2 visits) and hearing aid use (acceptability target: 80%; 95% CI: 71%-89%) for the intervention group and 50% difference between arms (95% CI: 31%-69%). Secondary outcomes included hearing aid fitting, cognition and other measures.

resultsFrom October 2018 to March 2020, 58 participants were recruited (29 per group, 95% [86%-99%]). Twenty-four participants were fitted with hearing aids in the intervention arm, and 6 in the control arm (difference: 62% [42%-82%]). At 6 months, retention was 81% [69%-90%]. Hearing intervention completion (≥2 visits) was achieved by 24 (83%). Daily hearing aid use was reported by 18 (75%) intervention versus 5 (22%) control participants, a difference of 53% [29%-77%].

conclusionRandomisation of people with MCI to a personalised hearing intervention versus control is feasible. These findings support proceeding to a fully-powered multicentre RCT.

Indexed as

Cognitive DysfunctionDementiaHearing AidsHearing LossAgedAged, 80 and overCognitionEarly DiagnosisFemaleHumansMaleMiddle AgedPilot ProjectsRisk FactorsTreatment Outcomecognitiondementiahearing lossmild cognitive impairmentolder peoplerandomised controlled trial

Identifiers

PMID39835654
PMCPMC11747994

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.