Evidence map›Paper›PMID 39835355›Full record

ArticleAging cell2025

Aging and Cancer-Inextricably Linked Across the Lifespan.

James DeGregori, Katherine J Seidl, Monty Montano

Abstract readEditorialClinical Study
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Thieno[3,2-International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James DeGregoriDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-1287-1976
Katherine J SeidlGlobal Head Oncology Drug Discovery Unit, Takeda Pharmaceuticals, Cambridge, Massachusetts, USA.
Monty MontanoDepartment of Medicine, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-8738-2838

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SHALENDER BHASIN · 2008 to 2026
$23.9M
Aged tissue environments as drivers of oncogenic adaptation in hematopoiesisR01AG066544 · NIA · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2020 to 2024
$1.1M
National Institute of Aging 5P30AG031679National Institute of Aging R01AG066544NIA NIH HHS P30 AG031679NIA NIH HHS R01 AG066544
6 · The paper itself

Abstract

Aging (as old man wind) alters the trajectory of cancer (dangerous seas) through changes in the immune system and metabolism (among many others), leading to altered cancer epidemiology, pathogenesis, and therapeutic responses, as represented by the research areas (boats)-artwork by Michael DeGregori.

Indexed as

AgingLongevityNeoplasmsHumans

Identifiers

PMID39835355
PMCPMC11984663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.