Evidence map›Paper›PMID 39835198›Full record

ArticleFrontiers in physiology2024

The effects of aerobic exercise and heat stress on the unbound fraction of caffeine.

Mackenzie McLaughlin, Kaye Dizon, Ira Jacobs

Abstract read
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Developmental age and clinical illness driveFrontiers in pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mackenzie McLaughlinHuman Physiology Research Unit, Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Kaye DizonDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Ira JacobsHuman Physiology Research Unit, Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The fraction of drug circulating in the blood that is not bound to plasma proteins ( Methods: Ten healthy participants (4 females and 6 males; age: 21.9 ± 2.7 years [means ± SD]) ingested 3 mg/kg of anhydrous caffeine on two separate occasions comprised of a control trial involving 105 min of rest, and an experimental trial involving 10 min of passive heating, followed by 20 min of cycling at 55% Results: The exercise protocol resulted in maximal increases in core temperature of 1.37°C ± 0.27°C and lactate of 10.34 ± 3.33 mmol/L, and a decrease in blood pH of 0.12 ± 0.051 (all Discussion: Therefore, the changes in blood temperature and pH in this study did not affect the

Indexed as

Centrifree®exercise hemodynamicsexercise pharmacokineticsmetabolic ratioplasma protein bindingQ10 effectultrafiltration

Identifiers

PMID39835198
PMCPMC11744008

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.