ArticleInfection and drug resistance2025
Nanobubble Ozone Stored in Hyaluronic Acid-Decorated Liposome Solutions: Inactivating Antibiotic-Resistant Bacteria and Genotoxicity, Sub-Acute and Sub-Chronic Toxicity Tests.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanism and clinical application of ozone therapy in treating skin ulcer diseases.Medical gas research · 2026Pooled it
- Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy.Nanomaterials (Basel, Switzerland) · 2025Review
- Efficacy of ultraviolet-light emitting diodes in bacterial inactivation and DNA damage via sensitivity evaluation using multiple wavelengths and bacterial strains.Archives of microbiology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Nanobubble ozone stored in hyaluronic acid-decorated liposomes (patent application PCT/TR2022/050177) was used, and the Minimum Inhibitory Concentration (MIC) was found to be 1562 ppm. Methods: Antibacterial tests of the nanobubble liposome solution, developed with a different technique than the standard ozonation procedures, were performed with the CLSI M07 A9 (Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard) standard test method, and the solution was tested at Minimal Inhibitory Concentration (MIC) value and time-dependent effects were determined. For the stability test of the nanobubble liposome solution, according to the ASTM F 1980 standard, it was kept at 55 °C for 74 days as two-year stability. Results: The MIC of the nanobubble ozone solution was 1.562 ppm for Conclusion: It is thought that nanobubble ozone stored in hyaluronic acid-decorated liposome solutions will play an important role in the fight against infections because of its non-toxic effect, effectiveness against resistant bacteria, and stability for at least two years. In the following process, it would be appropriate to support the product through clinical studies.
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Registered trials
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