ArticleCureus2024
Molecular Assay Versus Serology for Diagnosis of Scrub Typhus Among Patients With Acute Febrile Illness: A Retrospective Study.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectivesThe epidemiology of scrub typhus caused by
methodsThis retrospective study was accomplished at the Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, OR, IND. We analyzed the data of adult patients admitted with scrub typhus between March 2022 and February 2024, and their blood samples were evaluated with both IgM ELISA and DNA RT-PCR. The IgM antibody levels against
resultsOf the 231 patients scrutinized, 170 were deemed eligible. Sixty-five (38.2%) participants were female. The median age of the study subjects was 44.5 (24.0-61.8) years. All of them had fever. Other symptoms (in decreasing order of incidence) were as follows: cough (139, 81.8%), lymphadenopathy (29, 17.1%), rash (26, 15.3%), abdomen pain (18, 10.6%), eschar (6, 3.5%), and seizure (2, 1.2%). Maximum co-occurrence was observed between cough, lymphadenopathy, rash, and pain in the abdomen with fever. It held good for both females and males. The study population's median OD and CT values were 2.8 (0.8-3.7) and 41.0 (36.0-42.0), respectively. The OD and CT values were positively correlated (r = 0.78, 95% CI = 0.71-0.83, p < 0.001).
conclusionThe study participants had symptoms like fever, cough, lymphadenopathy, rash, pain in the abdomen, and eschar. Our findings suggest that ELISA and DNA RT-PCR could be used for scrub typhus diagnosis among patients with febrile illness for > 5 and ≤ 5 days, respectively. Both diagnostic methods were found to possess a positive correlation. The findings of ELISA and DNA RT-PCR must be probed further.
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