ArticleCureus2024
The Role of Nasal Microbiota and Sensitivity in Patients With Chronic Rhinosinusitis at a Rural Tertiary Care Hospital.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Surgical treatment of otogenic vertigo.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Review
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background and aim Etiopathogeneses of chronic rhinosinusitis are poorly understood. Recent research emphasizes culture-independent molecular sequencing to identify clusters of flora that may function as drivers of inflammation. Studies also indicate that macrolides are as effective as corticosteroids in controlling chronic rhinosinusitis. In this study, we aimed to isolate microbial cultures from the middle meatus of patients suffering from chronic rhinosinusitis and assess the isolates for similarities and antibiotic sensitivity. We also sought to identify the pathogenic species disrupting the nasal microbiome and provide appropriate antibiotics based on the least minimum inhibitory concentration (MIC) from the cultures. Disease progression and response to treatment were evaluated using the Sino-Nasal Outcome Test-22 (SNOT-22) and the Lund-Kennedy endoscopy scoring system. Specifically, diagnostic nasal endoscopy (DNE) was performed in patients with chronic rhinosinusitis without nasal polyps (CRSnNP), and the pre-treatment Lund-Kennedy score was recorded, along with subjective data collected from the SNOT-22 questionnaire. After isolating cultures from the middle meatus, antibiotic treatment was provided based on these findings. A repeat DNE was conducted to calculate the post-treatment Lund-Kennedy score and collect the post-treatment SNOT-22 score. Finally, the pre- and post-treatment scores were compared to assess any statistically significant differences. Methods The patients upon arrival to the hospital and diagnosed with chronic rhinosinusitis without nasal polyposis (CRSnNP) based on the joint EPOS 2020 Criterion for the same were enrolled in the study. The patients were administered an SNOT-22 Questionnaire for subjective evaluation. The patients underwent a diagnostic nasal endoscopy (DNE) to calculate the Lund-Kennedy score, take swabs from the middle meatus for culture and sensitivity, and provide objective evaluation by the assessing physicians. The scores were recorded at the first visit and on each visit till the two weeks of antibiotic treatment were completed. The patients were treated with antibiotics as per the cultured isolates. The Lund-Kennedy scores and SNOT-22 scores before and after treatment were compared to note the response to treatment. Results The mean average Lund-Kennedy score and SNOT-22 scores dropped following a course of antibiotics. The patients also experienced symptomatic relief. The most commonly isolated organism among the samples evaluated was
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