Evidence map›Paper›PMID 39834518›Full record

ArticleCurrent research in toxicology2025

The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity.

Yan Sai, Wei Ge, Li Zhong, Qifu Zhang, Jingsong Xiao, Yaohui Shan, Wenqi Ye, Haoyin Liu, Shulin Liu, Feng Ye and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yan SaiInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Wei GeInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Li ZhongInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Qifu ZhangInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Jingsong XiaoInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Yaohui ShanInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Wenqi YeInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Haoyin LiuInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Shulin LiuInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Feng YeInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Xiaogang WangInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
He TangInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Yuanpeng ZhaoInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Guorong DanInstitute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rotenone is a natural compound from plants. It is widely used in pesticides because of highly toxic to insects and fish. However, lots of research has reported that rotenone has neurotoxic effects in humans. It is confirmed there is a correlation between rotenone exposure and Parkinson's disease (PD). Therefore, the role of gut microbiota and related metabolic pathways was investigated in rotenone-induced neurotoxicity. The results showed that the abundance of gut microbiota changed significantly. The differential metabolites were enriched in the nicotinate and nicotinamide metabolism pathways, which had the greatest impact on the entire metabolic system. The contents of acetic acid and butyric acid in intestinal tissues decreased significantly. Additionally, Interleukin-6 (IL-6), Tumor necrosis factor alpha (TNF-α) and vasoactive intestinal peptide (VIP) were significantly up-regulated, while gastrin (GAS) and Ghrelin were significantly down-regulated. Expression of intestinal tight junction protein was significantly reduced. Moreover, nicotinamide adenine dinucleotide (NAD

Indexed as

Gut microbiotaInflammatory responseMetabolomicsNeurotoxicityNicotinate and nicotinamide metabolic pathwaysRotenone

Identifiers

PMID39834518
PMCPMC11743872

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.