ArticleFrontiers in cell and developmental biology2024
Meibomian gland alterations in allergic conjunctivitis: insights from a novel quantitative analysis algorithm.
Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Comparison of Meibomian Gland Loss Between Pediatric Patients with Blepharo-Keratoconjunctivitis and Age-Matched Controls Using Non-Contact Meibography.Journal of clinical medicine · 2026Article
- AI driven quantitative analysis of meibomian glands in children and adolescents: a benchmark dataset study.Eye and vision (London, England) · 2025Article
- Development and multicenter validation of an AI driven model for quantitative meibomian gland evaluation.NPJ digital medicine · 2025Article
- Reproducibility and accuracy of corneal curvature measurements in patients with and without dry eye: a device-based study.Frontiers in medicine · 2025Article
- A machine learning model for predicting anatomical response to Anti-VEGF therapy in diabetic macular edema.Frontiers in cell and developmental biology · 2025Article
- Tear film characteristics in French bulldogs vs. non-brachycephalic dogs.Frontiers in veterinary science · 2025Article
- A new digital biomarker ofFrontiers in cell and developmental biology · 2025Article
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11 authors.
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Abstract
Purpose: To investigate the changes in meibomian gland (MG) structure in allergic conjunctivitis (AC) patients using an intelligent quantitative analysis algorithm and to explore the relationship between these changes and clinical parameters. Methods: A total of 252 eyes from patients with AC and 200 eyes from normal controls were examined. Infrared meibography was performed using the non-contact mode of the Keratograph 5M. MG images were analyzed using a deep learning-based a quantitative analysis algorithm to evaluate gland length, area, dropout ratio, and deformation. Clinical parameters, including tear meniscus height, tear break up time (TBUT), conjunctival hyperemia, and Ocular Surface Disease Index (OSDI) scores, were assessed and correlated with changes in the structure of MG. Results: The average MG length in AC patients was 4.48 ± 1.04 mm, shorter compared to the control group (4.72 ± 0.94 mm). The average length of the central 5 glands in AC patients was 4.94 ± 1.67 mm, which was also shorter than the control group's central 5 glands (5.38 ± 1.42 mm). Furthermore, the central 5 glands' area in AC patients (1.61 ± 0.64 mm Conclusion: Through the intelligent quantitative algorithm, we found that AC leads to significant changes in MG structure, particularly affecting gland length and central area.
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