ArticleFrontiers in cell and developmental biology2024
A phase-transited lysozyme coating doped with strontium on titanium surface for bone repairing via enhanced osteogenesis and immunomodulatory.
Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Surface modifications of titanium dental implants: optimizing antibacterial activity and osteoimmunomodulation.Frontiers in bioengineering and biotechnology · 2026Review
- From Nutrition to Innovation: Biomedical Applications of Egg Components.Molecules (Basel, Switzerland) · 2025Review
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Authors and funding
7 authors.
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Abstract
Introduction: Titanium is currently recognized as an excellent orthopedic implant material, but it often leads to poor osseointegration of the implant, and is prone to aseptic loosening leading to implant failure. Therefore, biofunctionalization of titanium surfaces is needed to enhance their osseointegration and immunomodulation properties to reduce the risk of implant loosening. We concluded that the utilization of PTL-Sr is a direct and effective method for the fabrication of multifunctional implants. Methods: In this Study, phase-transited lysozyme (PTL) is deposited onto the surface of titanium (Ti) to construct a functional coating and strontium chloride solution was utilized to produce PTL coatings with Sr Results: The characterization indicates the successful preparation of PTL-Sr coatings. Discussion: Titanium with PTL-Sr coatings promote biomineralization and immunomodulation, which is suitable for orthopedic applications. Further mechanistic exploration and studies using animal models is necessary to enhance the understanding of the clinical applicability of modified titanium.
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