What We Know About TMEM175 in Parkinson's Disease.

Jing Wang, Xuechun Sun, Lufeng Cheng, Meijie Qu, Chanyuan Zhang, Xueting Li, Lingyan Zhou

Abstract readReview

In one paragraph

Review in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jing WangMedical Record Information Section, Yantai Yuhuangding Hospital, Yantai, Shandong, China.

Xuechun SunDepartment of Neurology, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Lufeng ChengDepartment of Neurology, Linyi People's Hospital, Linyi, Shandong, China.

Meijie QuDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Chanyuan ZhangDepartment of Otolaryngology and Head and Neck, Chongqing General Hospital, Chongqing, China.

Xueting LiDepartment of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou, China.

Lingyan ZhouDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.ORCID 0000-0002-3255-9736

Funding

Shandong Provincial Hospital Research Incubation Fund 2023FY061Shandong Provincial Natural Science Foundation ZR2024QH384

6 · The paper itself

Abstract

backgroundLysosome is a highly heterogeneous membranous organelle in eukaryotic cells, which regulates many physiological processes in the cell. Studies have found that lysosomal dysfunction disrupts cellular homeostasis and is associated with Parkinson's disease (PD). Transmembrane protein 175 (TMEM175) is a lysosomal cation channel whose activity is essential for lysosomal homeostasis. At present, it has been confirmed that TMEM175 is related to the pathogenesis of PD, but the relationship between the two remains unclear.

aimsA thorough comprehension of the structure and function of TMEM175 would greatly contribute to elucidating the achievement of this objective. In this paper, the structure, composition, and function of TMEM175 and its relationship with PD will be reviewed.

Indexed as

Membrane ProteinsParkinson DiseaseAnimalsHumansLysosomesPotassium ChannelsMembrane ProteinsPotassium ChannelsTMEM175 protein, humanlysosomeparkinson's diseaseproton channelTMEM175

Identifiers

PMID39834146

DOI10.1111/cns.70195

PMCPMC11746916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.