Evidence map›Paper›PMID 39834121›Full record

ArticleCancer biology & therapy2025

Fractionated radiotherapy initiated at the early stage of bone metastasis is effective to prolong survival in mouse model.

Yun Zhang, Zhunyi Gao, Ziwei Qi, Jiahe Xu, Jiao Xue, Lujie Xiong, Junhui Wang, Yuhui Huang, Songbing Qin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yun ZhangDepartment of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhunyi GaoDepartment of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ziwei QiCyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine and Prevention, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Jiahe XuDepartment of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jiao XueDepartment of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou, China.
Lujie XiongDepartment of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Junhui WangCyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine and Prevention, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Yuhui HuangCyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine and Prevention, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Songbing QinDepartment of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0001-7056-1741

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeBone metastasis is common for breast cancer and associated with poor prognosis. Currently, radiotherapy (RT) serves as the standard treatment for patients exhibiting symptoms of bone metastasis to alleviate pain. Whether earlier application of RT will better control bone metastasis remains unclear.

methodsWe utilized a mouse model of breast cancer bone metastasis by intra-femoral injection of 4T1-luc breast tumor cells. The bone metastasis was treated by RT using various doses, timings, and modalities. Tumor growth was assessed through bioluminescence imaging, and lung metastases was quantified following lung tissue fixation. Flow cytometry was employed to analyze alterations in immune cell populations.

resultsSingle high-dose RT suppressed tumor growth of bone metastases, but caused severe side effects. Conversely, fractionated RT mitigated tumor growth in bone metastases with fewer adverse effects. Fractioned RT initiated at the early stage of bone metastasis effectively inhibited tumor growth in the bone, suppressed secondary lung metastases, and prolonged mouse survival. In line with the known pro- and anti-metastatic effects of neutrophils and T cells in breast cancer, respectively, earlier fractioned RT consistently decreased the proportions of neutrophils while increased the proportions of T cells in both the bone and the lung tissues.

conclusionThe data suggest that fractionated RT can inhibit the progression of early stage of bone metastasis and reduce secondary lung metastasis, leading to favorable outcomes. Therefore, these findings provide preclinical evidence to support the application of fractionated RT to treat patients with bone metastasis as earlier as possible.

Indexed as

Bone NeoplasmsBreast NeoplasmsDose Fractionation, RadiationAnimalsCell Line, TumorDisease Models, AnimalFemaleHumansLung NeoplasmsMiceMice, Inbred BALB Cbone metastasisearly stageFractionated radiotherapyimmune cellssecondary lung metastasis

Identifiers

PMID39834121
PMCPMC12724103

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.