Evidence map›Paper›PMID 39834031›Full record

ArticleOphthalmic genetics2025

Antioxidant MitoQ increases viability of human corneal endothelial cells with congenital hereditary endothelial dystrophy-associated

Saloni Peshkar-Kulkarni, Doug D Chung, Anthony J Aldave

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Saloni Peshkar-KulkarniDepartment of Ophthalmology, Stein Eye Institute at UCLA, Los Angeles, California, USA.
Doug D ChungDepartment of Ophthalmology, Stein Eye Institute at UCLA, Los Angeles, California, USA.ORCID 0000-0002-8505-9495
Anthony J AldaveDepartment of Ophthalmology, Stein Eye Institute at UCLA, Los Angeles, California, USA.

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID S WILLIAMS · 1985 to 2026
$16.8M
NEI NIH HHS P30 EY000331
6 · The paper itself

Abstract

purposeTo assess the impact of MitoQ, a mitochondria-targeted antioxidant, on viability of human corneal endothelial cell (hCEnC) lines expressing

methods

results

conclusionsMedia supplementation with antioxidant MitoQ has beneficial effects on cell viability in hCEnC harboring CHED-associated

Indexed as

Anion Transport ProteinsAntioxidantsAntiportersCorneal Dystrophies, HereditaryEndothelium, CornealFuchs' Endothelial DystrophyMutationOrganophosphorus CompoundsUbiquinoneCells, CulturedCell SurvivalHumansOxidative StressAnion Transport ProteinsAntioxidantsAntiportersmitoquinoneOrganophosphorus CompoundsSLC4A11 protein, humanUbiquinonecongenital hereditary endothelial dystrophy (CHED)Corneal endothelial cellsFuchs endothelial corneal dystrophy (FECD)oxidative stressSLC4A11

Identifiers

PMID39834031
PMCPMC12003074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.