Evidence map›Paper›PMID 39834028›Full record

ArticleThe Clinical neuropsychologist2025

Single- versus two-test criteria for cognitive impairment: associations with CSF and imaging markers in former American football players.

Monica T Ly, Caroline Altaras, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Henrik Zetterberg, Kaj Blennow, Elaine R Peskind, Sarah J Banks and 20 more

Abstract readComparative Study
In one paragraph

Article in The Clinical neuropsychologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Monica T LyDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-4842-9047
Caroline AltarasDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Yorghos TripodisDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Charles H AdlerDepartment of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Laura J BalcerDepartments of Neurology, Population Health and Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA.
Charles BernickCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Henrik ZetterbergDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Kaj BlennowClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Elaine R PeskindVA Northwest Mental Illness Research, Education, and Clinical Center, Seattle, WA, USA.
Sarah J BanksDepartment of Psychiatry, University of California San Diego Health, La Jolla, CA, USA.
William B BarrDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Jennifer V WetheDepartment of Psychiatry and Psychology, Mayo Clinic School of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Steve LenioDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Mark W BondiDepartment of Psychiatry, University of California San Diego Health, La Jolla, CA, USA.
Lisa M Delano-WoodDepartment of Psychiatry, University of California San Diego Health, La Jolla, CA, USA.
Robert C CantuDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Michael J ColemanPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
David W DodickDepartment of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Jesse MezDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Daniel H DaneshvarDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.
Joseph N PalmisanoBiostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health, Boston, MA, USA.
Brett MartinBiostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health, Boston, MA, USA.
Alexander P LinPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Inga K KoertePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Sylvain BouixPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Jeffrey L CummingsChambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, NV, USA.ORCID 0000-0001-8944-4158
Eric M ReimanBanner Alzheimer's Institute, Phoenix, AZ, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Robert A SternDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Michael L AloscoDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
RL5: Research Education CoreP30AG072978 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ann C. McKee · 2021 to 2026
$25.6M
Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI Robert J. Fox, Jefferson Kinney · 2015 to 2026
$22.8M
Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project IIR01NS139383 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Alosco, Nicholas Ashton · 2024 to 2026
$9.3M
Alzheimer's Clinical Trial InnOvatioN (ACTION) InitiativeR35AG071476 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI CUMMINGS, JEFFREY L. · 2021 to 2025
$2.9M
Sex Differences in Brain Structure and Function After Sports-Related ConcussionR01NS100952 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KOERTE, INGA KATHARINA · 2017 to 2022
$2.9M
Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric SymptomsRF1NS122854 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ALOSCO, MICHAEL, MCKEE, ANN C. · 2021 to 2021
$2.3M
Chronic Traumatic Encephalopathy: Clinical Presentation and BiomarkersR01NS078337 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STERN, ROBERT A · 2011 to 2013
$2.0M
Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric SymptomsR01NS122854 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ALOSCO, MICHAEL, MCKEE, ANN C. · 2024 to 2025
$1.6M
Alzheimer's Disease and Related Dementias Innovation Incubator (InnovaTor)R25AG083721 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI JEFFREY L. CUMMINGS, Xue K Zhong · 2023 to 2026
$1.0M
NCATS NIH HHS UL1 TR001430NIA NIH HHS K01 AG054762NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG072978NIA NIH HHS R25 AG083721NIA NIH HHS R35 AG071476NIGMS NIH HHS P20 GM109025NINDS NIH HHS K23 NS102399NINDS NIH HHS R01 NS078337NINDS NIH HHS R01 NS100952NINDS NIH HHS R01 NS122854NINDS NIH HHS R01 NS139383NINDS NIH HHS RF1 NS122854NINDS NIH HHS U01 NS093334
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chronic Traumatic EncephalopathyCognitive DysfunctionFootballNeuropsychological TestsAdultAmyloid beta-PeptidesBiomarkersHumansMagnetic Resonance ImagingMaleMiddle AgedNeurofilament ProteinsPeptide Fragmentstau ProteinsUnited StatesAmyloid beta-PeptidesBiomarkersneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau Proteinsaxonal injurycognitive impairmentneurodegenerationrepeated head traumarepetitive head impacttraumatic encephalopathy syndrome

Identifiers

PMID39834028
PMCPMC12276947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.