ArticleItalian journal of pediatrics2025
A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease.
Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis:Sultan Qaboos University medical journal · 2025Pooled it
- Clinical characteristics and predictors of severe pertussis in hospitalized children after the COVID-19 period in Türkiye: a multicenter study.European journal of pediatrics · 2026Article
- Diagnostic Performance and Clinical Outcomes of Pertussis in Hospitalized Children in Relation to Available Vaccination Status: A Retrospective Cohort Study.Infectious diseases and therapy · 2026Article
- Pertussis-SARS-CoV-2 Co-infection in Infants at Mohammed VI University Hospital, Marrakech, Morocco.Cureus · 2026Article
- Clinical features, disease severity, and outcomes of pertussis in hospitalized children: A retrospective study from Serbia.PloS one · 2026Article
- Risk factors for pneumonia in children withOpen medicine (Warsaw, Poland) · 2026Article
- The Bordetella type III secretion system effector BteA targets host eosinophil-epithelial signaling to promote IL-1Ra expression and persistence.Communications biology · 2025Article
- Retrospective analysis of 104 cases of pediatric severe pertussis in Southern China.BMC infectious diseases · 2025Article
- Positivity analysis ofMicrobiology spectrum · 2025Article
- Epidemiological and clinical characteristics of pertussis in pediatric population: a multicenter study of 20,727 children in Hubei, China.BMC infectious diseases · 2025Article
- Bordetella Pertussis in Children: A Retrospective Analysis of the Clinical Impact and the Role of Vaccination.Life (Basel, Switzerland) · 2025Article
- Resurgence ofMicroorganisms · 2025Article
- A retrospective study on pediatric pertussis: comprehensive evaluation of symptoms, laboratory indicators, and diagnostic efficacy of case definitions.Frontiers in cellular and infection microbiology · 2025Article
- Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024.Frontiers in public health · 2025Article
- Co-infection in pediatric pertussis during 2023 and 2024 in southern China: pathogen distribution characteristic and influence on manifestation of pertussis.Frontiers in microbiology · 2025Article
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17 authors.
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Abstract
backgroundIn recent months, Bordetella pertussis has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study, we evaluate B.pertussis cases observed in the pediatric population followed at the Bambino Gesù Children's Hospital and analyzed the potential impact of co-infections in relation to disease severity.
methodsFrom January to May 2024, a total of 1,151 children and adolescents (both inpatients and outpatients) were screened for the presence of respiratory pathogens, including B.pertussis, with clinically relevant respiratory symptoms.
resultsAmong the 1,151 patients screened, 66 tested positive for B.pertussis. Fourteen patients had respiratory failure, and six of them required intensive care unit (ICU) admission, while 52 had mild infection. 23.3% of patients had B.pertussis alone, while 76.7% had co-infections (including 5 patients admitted to the ICU). A higher co-infection rate was observed in patients with respiratory failure than in those without failure (92.9% vs. 69.0%, p-value:0.041). Rhinovirus, Metapneumovirus and Parainfluenza-virus were the most prevalent in our pediatric population. Co-infections of human bocavirus with B.pertussis were observed exclusively in patients with respiratory failure.
conclusionsOur results highlighted an increase in B.pertussis cases from January to May 2024, reaching a peak of cases in the month of May. This study shows a high rate of B.pertussis co-infection, and a trend toward association between B.pertussis and specific viruses, that might play a role in increasing disease severity.
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