Evidence map›Paper›PMID 39833741›Full record

ArticleBMC neurology2025

Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report.

Zhengping Cheng, Yang Song, Shuqi Zhao, Xiaowen Sui, Lili Xie, Hongling Zhao, Xin Pan, Li Cui, Xinran Huang, Shubei Ma

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhengping Cheng *Neurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Yang Song *Hematology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Shuqi ZhaoNeurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Xiaowen SuiNeurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Lili XieNeurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Hongling ZhaoNeurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Xin PanNeurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Li CuiNeurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Xinran HuangHematology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China.
Shubei MaNeurology Department, Central Hospital of Dalian University of Technology, Dalian City, 116000, China. mshb1980@vip.163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutoimmune encephalitis associated with anti-GluK2 antibodies is a recently identified condition, typically characterized by cerebellar ataxia. This case report presents a unique clinical manifestation involving involuntary movements and emotional dysregulation, expanding the known phenotype spectrum. CASE PRESENTATION: A 60-year-old woman presented with a two-year history of involuntary movements predominantly affecting her lower limbs and facial muscles, occasionally accompanied by hysterical shouting. Initial investigations revealed coexisting multiple myeloma (MM) and anti-GluK2 antibody positivity. Following MM-specific therapy, including bortezomib, cyclophosphamide, and dexamethasone, the patient's symptoms resolved, and her serum anti-GluK2 antibody titers decreased significantly.

conclusionsThis case suggests that involuntary movements and psychiatric symptoms may represent novel phenotypes of anti-GluK2 antibody-associated autoimmune encephalitis. The findings underscore the importance of recognizing the diverse clinical presentations of this rare condition and prompt further research into its underlying mechanisms.

Indexed as

AutoantibodiesEncephalitisHashimoto DiseaseMultiple MyelomaFemaleHumansMiddle AgedAutoantibodiesAlginate-type glutamate receptor subunit 2 (GluK2) encephalitisInvoluntary movementMultiple myeloma

Identifiers

PMID39833741
PMCPMC11744977

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.