Evidence map›Paper›PMID 39833672›Full record

Trial reportBMC anesthesiology2025

The efficacy and safety of patient-controlled intravenous analgesia with esketamine after total hip arthroplasty: a randomized controlled trial.

Song Qu, Wen-Jie Zhang, Hai-Jiao Zhou, Fei Deng, Rui-Juan Liu, Wen-Jun Yan

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Song QuDepartment of Anesthesiology, Guizhou Hospital The First Affiliated Hospital of Sun Yat-sen University, GuiYang, China.
Wen-Jie ZhangDepartment of Anesthesiology, Affiliated Hospital of Shandong Second Medical University, WeiFang, China.
Hai-Jiao ZhouAnesthesiology and Operation Department, Gansu Provincial Hospital, Lanzhou, China.
Fei DengAnesthesiology and Operation Department, Gansu Provincial Hospital, Lanzhou, China.
Rui-Juan LiuAnesthesiology and Operation Department, Gansu Provincial Hospital, Lanzhou, China.
Wen-Jun YanAnesthesiology and Operation Department, Gansu Provincial Hospital, Lanzhou, China. 13893370700@163.com.

Funding

Gansu natural science foundation 21JR7RA621Gansu Province Anesthesia and Brain Function Clinical Medical Research Center 21JR7RA675Gansu province Key research plan 23YFFA0046The National Nature Science Fundition of China 81860233
6 · The paper itself

Abstract

purposeTo evaluate the efficacy and safety of esketamine-based patient-controlled intravenous analgesia following total hip arthroplasty.

methodsA total of 135 total hip arthroplasty patients were randomly assigned to one of the three treatment groups: esketamine, sufentanil or continuous fascia iliaca compartment block (FICB) group. The primary endpoint was the postoperative visual analogue scale (VAS) pain scores at rest and on movement. Secondary endpoints included preoperative 1-day and postoperative 7-day Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores, the satisfaction of patients and surgeons, postoperative 1-month and 3-month Harris function scores, the incidence of adverse reactions.

resultsAt 48 h post-surgery, the VAS pain scores in the esketamine and FICB groups at rest and on movement were significantly lower than those in the sufentanil group (P < 0.05). The satisfaction of patients in the esketamine group was higher than that in the sufentanil and FICB groups (P = 0.014). The satisfaction of surgeons in the esketamine and FICB groups was higher than that in the sufentanil group (P = 0.002). At postoperative day 7, the SAS scores and SDS scores in the esketamine group were significantly lower than those in the sufentanil and FICB groups (P < 0.05). Compared with the sufentanil group, the postoperative nausea and vomiting, dizziness and total adverse reactions in the esketamine group and FICB group were lower (P < 0.05).

conclusionPatient-controlled intravenous analgesia with esketamine has the potential to provide good postoperative analgesia for total hip arthroplasty patients, reduce the incidence of adverse reactions after the operation, improve the satisfaction of patients and surgeons, and significantly improve patients' postoperative mood.

trial registrationChiCTR2300069632 ( https://www.chictr.org.cn/ ) (March 22th, 2023).

Indexed as

Analgesia, Patient-ControlledAnalgesicsArthroplasty, Replacement, HipKetaminePostoperative PainAgedAnalgesics, OpioidFemaleHumansMaleMiddle AgedPain MeasurementPatient SatisfactionSufentanilTreatment OutcomeAnalgesicsAnalgesics, OpioidEsketamineKetamineSufentanilEsketamineFascia Iliaca compartment blockPatient controlled intravenous analgesiaPostoperative painTotal hip arthroplasty

Identifiers

PMID39833672
PMCPMC11744849

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.