Evidence map›Paper›PMID 39833666›Full record

ArticleInternational journal of emergency medicine2025

A case of stroke as a unique sign of subclinical infective endocarditis by Abiotrophia defectiva: a case report.

Silvia Puxeddu, Valeria Virdis, Daniele Sacco, Mario Depau, Alessandro M Atzei, Lorella Pisano, Marcello Di Rosa, Stefania Vacquer, Giorgio Accardi, Emiliano M Cirio and 3 more

Abstract read
In one paragraph

Article in International journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Silvia PuxedduMicrobiology and Virology Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Valeria VirdisLaboratory of Clinical and Microbiological Analysis, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Daniele SaccoLaboratory of Clinical and Microbiological Analysis, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Mario DepauLaboratory of Clinical and Microbiological Analysis, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy. mariodottdepau@gmail.com.
Alessandro M AtzeiCardiology Unit, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Lorella PisanoCardiac Surgery Unit, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Marcello Di RosaLaboratory of Clinical and Microbiological Analysis, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Stefania VacquerLaboratory of Clinical and Microbiological Analysis, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Giorgio AccardiInfectious Diseases Clinic, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Emiliano M CirioCardiac Surgery Unit, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Aldo ManzinMicrobiology and Virology Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Cristiana MarinelliLaboratory of Clinical and Microbiological Analysis, ARNAS "G. Brotzu" Hospital Cagliari, Cagliari, Italy.
Fabrizio AngiusMicrobiology and Virology Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. fangius@unica.it.

Funding

Next Generation EU-MUR PNRR PE00000007 - INF-ACT
6 · The paper itself

Abstract

purposeHere we describe a patient admitted for a stroke that was unexpectedly correlated with subclinical infective endocarditis attributable to a rarely opportunistic pathogen, Abiotrophia defectiva. CASE REPORT: A 75-year-old man presented with a stroke. Transesophageal echocardiography suggested vegetation on all aortic valve cusps, despite the absence of clinical or laboratory signs of infection. Surprisingly, three sets of blood cultures collected without fever were positive for A. defectiva. Although the patient did not exhibit classic signs of infection during hospitalization, the severity of the valve condition necessitated replacement with a bioprosthesis.

conclusionsThis clinical case underscores the importance of investigating the infective origin of endocarditis, even in the absence of clinical or laboratory evidence. Physicians should maintain a high level of suspicion, especially in patients with highly suggestive anamnestic characteristics.

Indexed as

Abiotrophia defectivaBlood culturesCase reportInfective endocarditisMALDI-TOFValve replacement

Identifiers

PMID39833666
PMCPMC11744866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.