ArticleThe Journal of clinical endocrinology and metabolism2025
Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of acupuncture therapies for polycystic ovary syndrome: a network meta-analysis.Frontiers in medicine · 2026Pooled it
- Body mass index and subsequent fracture risk: a meta-analysis to update FRAX.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Pooled it
- Sex differences in glucose-regulating neurohormonal pathways-potential impact for type 2 diabetes development.Journal of the Endocrine Society · 2026Article
- Targeting Aromatase and 5-α-Reductase to Limit Dysfunctional Adipogenesis in Multiple Symmetric Lipomatosis.Biomedicines · 2026Article
- Association between dynamic abdominal obesity (DAO) and benign prostatic hyperplasia (lower urinary tract symptoms): evidence from the China Health and Retirement Longitudinal Study (CHARLS).World journal of urology · 2026Article
- Sex-Specific Effects of Obesity Severity on Circulating Inflammatory Mediators and Immune Cell Gene Expression.International journal of molecular sciences · 2026Article
- Low Testosterone in Men With Type 2 Diabetes: The Role of Estrogen Excess and Aromatase Activity.Clinical endocrinology · 2026Article
- Lifestyle Intervention Therapy Modulates Global DNA Methylation and Adipogenic Gene Expression in Severely Obese Hypogonadal Men.Metabolites · 2026Article
- Sex hormone-psoriasis interactions: from sex-specific clinical features to immunoregulatory mechanisms.Frontiers in immunology · 2026Review
- The mediating role of testosterone in the relationship between body fat percentage and diabetes mellitus risk.Frontiers in endocrinology · 2026Article
- Effects of cafeteria diet and caloric restriction on pituitary hormones and metabolic phenotype in male Wistar rats.Endocrine · 2025Article
- Article
- Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- Heterogeneity of effect of Intensive lifestyle intervention on cardiometabolic risk factors by sex hormones in diabetes.medRxiv : the preprint server for health sciences · 2025Article
- The Acute Effects of Morning Bright Light on the Human White Adipose Tissue Transcriptome: Exploratory Post Hoc Analysis.Clocks & sleep · 2025Article
- Metabolic Messengers: oestradiol.Nature metabolism · 2025Review
- Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan.Frontiers in endocrinology · 2025Review
- Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial.Open medicine (Warsaw, Poland) · 2025Article
- Association between the oxidative balance score and testosterone deficiency in males: a cross-sectional study.Frontiers in nutrition · 2025Article
- Clinical Presentation of a Patient With Hemochromatosis After Bariatric Surgery With HFE (H63D) Mutation.Journal of investigative medicine high impact case reportsArticle
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12 authors.
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Abstract
contextObesity and insulin resistance in men are linked to decreased testosterone and increased estradiol (E2) levels. Aromatase (ARO) converts testosterone into E2, and this occurs mainly in adipose tissue in men. E2 acts through estrogen receptors ESR1 and ESR2, and they potentially affect development of type 2 diabetes (T2D).
objectiveThis study explored alterations in ARO, ESR1, and ESR2 in men with obesity or T2D.
methodsSubcutaneous adipose tissue (SAT) from men with or without obesity or T2D was analyzed for ARO, ESR1, and ESR2 gene and protein expression. Data were compared across groups and correlated with markers of obesity, glycemia, insulin resistance, and sex hormones. Moreover, SAT was incubated with E2 or testosterone for ex vivo glucose uptake measurements.
resultsARO levels were higher in SAT from men with obesity compared to nonobese men, and gene expression correlated positively with adiposity, hyperglycemia, and insulin resistance. No association was found between ARO and circulating E2. Men with obesity had lower levels of ESR1 and ESR1:ESR2 ratio, but not ESR2. ESR1 gene expression in SAT correlated negatively with adiposity and insulin resistance markers as well as with ARO expression, and tended to be lower in men with T2D. E2 reduced insulin-stimulated glucose uptake, while testosterone increased basal glucose uptake in adipocytes.
conclusionElevated ARO in SAT was found in obese men, and this was linked to insulin resistance and glycemia, supporting the idea that local estrogen production contributes to metabolic dysregulation. ESR1 was reduced in men with T2D and was linked to adiposity and insulin resistance. Taken together, high ARO and altered ESR1:ESR2 balance in SAT in obese men may contribute to insulin resistance and T2D development.
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