ArticleClinical oral investigations2025
Impact of nanostructured additives in tooth bleaching agents on enhancing color change and reducing side effects: a scoping review.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical evaluation of in-office bleaching with low, medium, and high concentrate hydrogen peroxide: a 6-month a double-blinded randomized controlled trial.Clinical oral investigations · 2025Trial
- How TiOInternational journal of nanomedicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to determine whether incorporating nanostructured additives into bleaching agents enhances efficacy and reduces side effects while identifying gaps for further investigation.
methodsA comprehensive search was conducted in electronic databases, including PubMed/Medline, Embase, Scopus, and ISI Web of Science. Two reviewers independently screened articles based on predefined criteria, resolving discrepancies through discussion or consultation with a third reviewer. Data extraction focused on key details, including study design, interventions, and outcomes.
resultsTwenty-one articles were reviewed, consisting of nine clinical studies, one in vivo/in situ study, and 11 in vitro studies on tooth bleaching protocols. Hydrogen peroxide was the most commonly used bleaching agent. The primary nanostructured additives studied were titanium dioxide nanoparticles, polymeric carbamide peroxide nanoparticles, chitosan nanoparticles, nano-hydroxyapatite, SiO2/MgO/Fe2O3 nanocomposite spheres, and nano-bioactive glass. Most studies demonstrated an enhanced bleaching effect, reduced bleaching sensitivity, decreased cytotoxicity, reduced hydrogen peroxide penetration into the pulp chamber, and protection of the tooth surface against mineral and structural loss when nanostructured additives were incorporated into the bleaching agent.
conclusionsIncorporating nanostructured additives into tooth-bleaching agents improved efficacy and reduced side effects, especially with titanium oxide nanoparticles. Further clinical studies and systematic reviews are needed to establish strong evidence for safe clinical practice. CLINICAL RELEVANCE: Including nanostructured additives in bleaching agents, such as titanium oxide nanoparticles, might be a valuable approach to enhancing the bleaching potential while reducing bleaching sensitivity and cytotoxicity, offering safer alternatives for clinical protocols.
Indexed as
Identifiers
39833560What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.