Evidence map›Paper›PMID 39833550›Full record

ArticleHistochemistry and cell biology2025

mTORC1 regulates the proliferation of SOX9

Ming-Xin Zang, Geng Zhang, Ying Zhang, Sha-Sha Wang, Xiang-Wei Zhai, Na Zhao, Wei Ge, Jin-Wen Xie, Wei Shen, Shun-Feng Cheng

Abstract read
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In one paragraph

Article in Histochemistry and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ming-Xin Zang *College of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China.
Geng Zhang *College of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China.
Ying ZhangCollege of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China.
Sha-Sha WangQingdao Animal Husbandry and Veterinary Institute, Qingdao, 266000, Shandong, China.
Xiang-Wei ZhaiAnimal Husbandry General Station of Shandong Province, Jinan, 250010, China.
Na ZhaoCollege of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China.
Wei GeCollege of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China.
Jin-Wen XieShandong Binzhou Animal Science and Veterinary Medicine Academy, Binzhou, 256600, China.
Wei ShenCollege of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China.
Shun-Feng ChengCollege of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China. sfcheng@qau.edu.cn.

Funding

National Natural Science Foundation of China 32072734National Natural Science Foundation of China 32100683Natural Science Foundation of Shandong Province ZR2021QC003Qingdao Science and Technology Benefit the People Demonstration and Guidance Special Project 23-1-3-3-zyyd-nshShandong Taishan Scholars Construction Foundation ts20190946Shandong Taishan Scholars Construction Foundation tsqn202211194Start-up Fund for High-level Talents of Qingdao Agricultural University 6651121003
6 · The paper itself

Abstract

Skin-derived stem cells (SDSCs) are a subtype of adult stem cells (ASCs) that are widely harvested and exempt from ethical restrictions in clinical applications. These cells possess capabilities for self-renewal, proliferation, and multi-lineage differentiation. Compared to model animals like rats and mice, pigs exhibit greater physiological similarity to humans. Porcine skin has very similar histological and physiological characteristics to human skin. Therefore, porcine skin is becoming increasingly significant as an in vitro model for research. In this study, porcine skin-derived stem cells (pSDSCs) were isolated and cultured in vitro for experiments. The expression of stemness-related gene SOX9 was detected. RNA sequencing (RNA-seq) results found that the mammalian target of rapamycin (mTOR) signaling pathway was significantly enriched in SOX9

Indexed as

Mechanistic Target of Rapamycin Complex 1Ribosomal Protein S6 KinasesSkinSOX9 Transcription FactorStem CellsAnimalsCell ProliferationCells, CulturedPhosphorylationSwineMechanistic Target of Rapamycin Complex 1Ribosomal Protein S6 KinasesSOX9 Transcription FactormTORC1mTOR signaling pathwayProliferationpSDSCs

Identifiers

PMID39833550

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.