Evidence map›Paper›PMID 39833503›Full record

ArticleNPJ digital medicine2025

Equitable artificial intelligence for glaucoma screening with fair identity normalization.

Min Shi, Yan Luo, Yu Tian, Lucy Q Shen, Nazlee Zebardast, Mohammad Eslami, Saber Kazeminasab, Michael V Boland, David S Friedman, Louis R Pasquale and 1 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Artificial intelligence in ophthalmology: opportunities, challenges, and ethical considerations.Medical hypothesis, discovery & innovation ophthalmology journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min Shi *Harvard Ophthalmology AI Lab, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Yan Luo *Harvard Ophthalmology AI Lab, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5135-0316
Yu TianHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Lucy Q ShenMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Nazlee ZebardastMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1763-9401
Mohammad EslamiHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6570-2826
Saber KazeminasabHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Michael V BolandMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2506-7095
David S FriedmanMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Louis R PasqualeEye and Vision Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mengyu WangHarvard Ophthalmology AI Lab, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA. mengyu_wang@meei.harvard.edu.ORCID http://orcid.org/0000-0002-7188-7126

Funding

Developing Population-Generalizable Deep Learning Models for Automated Glaucoma ScreeningR01EY036222 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Mengyu Wang · 2024 to 2026
$2.0M
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related StructureR00EY028631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2021 to 2023
$741k
Personalizing Circumpapillary Retinal Nerve Fiber Layer Thickness Norms for GlaucomaR21EY035298 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2023 to 2023
$557k
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related StructureK99EY028631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2019 to 2020
$293k
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) EY028631NEI NIH HHS K99 EY028631NEI NIH HHS R00 EY028631NEI NIH HHS R01 EY036222NEI NIH HHS R21 EY035298
6 · The paper itself

Abstract

Glaucoma is the leading cause of irreversible blindness globally. Research indicates a disproportionate impact of glaucoma on racial and ethnic minorities. Existing deep learning models for glaucoma detection might not achieve equitable performance across diverse identity groups. We developed fair identify normalization (FIN) module to equalize the feature importance across different identity groups to improve model performance equity. The optical coherence tomography (OCT) measurements were used to categorize patients into glaucoma and non-glaucoma. The equity-scaled area under the receiver operating characteristic curve (ES-AUC) was adopted to quantify model performance equity. With FIN for racial groups, the overall AUC and ES-AUC increased from 0.82 to 0.85 and 0.77 to 0.81, respectively, with the AUC for Blacks increasing from 0.77 to 0.82. With FIN for ethnic groups, the overall AUC and ES-AUC increased from 0.82 to 0.84 and 0.77 to 0.80, respectively, with the AUC for Hispanics increasing from 0.75 to 0.79.

Identifiers

PMID39833503
PMCPMC11747341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.