Evidence map›Paper›PMID 39833445›Full record

ArticleScientific reports2025

Tilia species (linden) exert anti-cancer effects on MIA PaCa-2 cells through the modulation of oxidative stress and inflammation.

Gamze Yüksel, Yağmur Özhan, Dilara Güreşçi, Etil Güzelmeriç, Nisa Beril Şen, İpek Bedir, Onur Senol, Gizem Emre, Dilek Telci, Vilma Petrikaitė and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gamze YükselFaculty of Pharmacy, Department of Toxicology, Yeditepe University, 34755, Istanbul, Türkiye.
Yağmur ÖzhanFaculty of Pharmacy, Department of Toxicology, Yeditepe University, 34755, Istanbul, Türkiye.
Dilara GüreşçiFaculty of Pharmacy, Department of Toxicology, Yeditepe University, 34755, Istanbul, Türkiye.
Etil GüzelmeriçFaculty of Pharmacy, Department of Pharmacognosy, Yeditepe University, 34755, Istanbul, Türkiye.
Nisa Beril ŞenFaculty of Pharmacy, Department of Pharmacognosy, Yeditepe University, 34755, Istanbul, Türkiye.
İpek BedirDepartment of Genetics and Bioengineering, Yeditepe University, 34755, Istanbul, Türkiye.
Onur SenolEast Anatolian High Technology Research and Application Center (DAYTAM), Atatürk University, 25240, Erzurum, Türkiye.
Gizem EmreFaculty of Pharmacy, Department of Pharmaceutical Botany, Marmara University, 34854, Istanbul, Türkiye.
Dilek TelciDepartment of Genetics and Bioengineering, Yeditepe University, 34755, Istanbul, Türkiye.
Vilma PetrikaitėLithuanian University of Health Sciences, LT-44307, Kaunas, Lithuania.
Hande SipahiFaculty of Pharmacy, Department of Toxicology, Yeditepe University, 34755, Istanbul, Türkiye. hande.sipahi@yeditepe.edu.tr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the anti-cancer effects of the chemically characterized Tilia species (linden) on MIA PaCa-2 cells by analyzing various cancer-triggering mechanisms, including oxidative stress and inflammation status. Extracts from the flowers, bracts, and inflorescences of T. cordata, T. platyphyllos, T. rubra, and T. tomentosa were evaluated for antioxidant activity; subsequently, their ability to mitigate inflammation was assessed through in vitro nitrite assays in LPS-induced RAW264.7 cells. The anticancer potentials of the extracts against MIA PaCa-2 pancreatic cancer cells were investigated in 2D (cytotoxic effect) and 3D (effect on spheroid growth) models in vitro. All investigated Tilia species displayed remarkable antioxidant activity and significantly inhibited LPS-induced nitrite, IL-6, and PGE

Indexed as

Antineoplastic Agents, PhytogenicInflammationOxidative StressPancreatic NeoplasmsPlant ExtractsTiliaAnimalsAntioxidantsCell Line, TumorCell SurvivalHumansMiceRAW 264.7 CellsAntineoplastic Agents, PhytogenicAntioxidantsPlant Extracts3D spheroid modelAnticancer activityAnti-inflammatory activityAntioxidant activityPhenolic profileTilia species

Identifiers

PMID39833445
PMCPMC11747248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.