ArticleScientific reports2025
Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Evaluate the prognostic performance of the lactate-to-albumin ratio (LAR) for complications in children 5 years of age or younger with second and/or third degree burn injuries during hospitalization in the intensive care unit of a hospital in Lima, Peru. In this retrospective cohort study, we conducted prognostic tests by analyzing the medical records of children aged ≤ 5 years who suffered second- and/or third-degree burn injuries and were subsequently admitted to the ICU of a Lima-based hospital between 2017 and 2022. The LAR was calculated using lactate and albumin values measured within the first 48 h post-burn. The area under the curve (AUC) was utilized to evaluate the prognostic performance of the LAR in predicting complications. A cohort of 258 patients aged ≤ 5 years with second- and/or third-degree burn injuries was examined. Among them, 63 patients experienced complications (24.4%). The estimated AUC ROC for the LAR was 0.63 (95% confidence interval [CI]: 0.54-0.71). After adjusting for confounders, values of LAR above the threshold were found to be associated with a significantly increased risk of complications (adjusted relative risk: 2.23; 95% CI 1.51-3.29; p < 0.001). The LAR exhibited limited prognostic capability for complications in pediatric burn patients. Nevertheless, a significant association was observed between values of LAR above the threshold and increased risk of complications.
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