ArticleScientific reports2025
Long-term outcomes and lymph node metastasis following endoscopic resection with additional surgery or primary surgery for T1 colorectal cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Young age or surgical selection? Interpreting lymph-node metastasis risk in T1 colorectal cancer.Journal of gastroenterology · 2026Article
- A machine learning-based transcriptomic signature for predicting tumor recurrence after curative resection in T1 colorectal cancer: a retrospective multicenter cohort study (The Tw1CE trial).International journal of surgery (London, England) · 2026Article
- [Technical advances in endoscopic resection : Potential, limits and the necessary interdisciplinary dialogue with surgery].Innere Medizin (Heidelberg, Germany) · 2026Review
- Case Report: Rare case of primary rectal adenocarcinoma presenting as a smooth submucosal elevation: endoscopic submucosal excavation and 4 years and 11 months follow-up.Frontiers in medicine · 2026Article
- The Role of Pan-Cytokeratin In Tumor Budding Upgrading In Malignant Colorectal Polyps At Stage pT1.Cancer management and research · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimal management of T1 colorectal cancer (CRC) remains controversial. This study compared the long-term outcomes of endoscopic resection with additional surgical resection (ER + ASR) versus primary surgical resection (PS) in patients with T1 CRC and identified risk factors for lymph node metastasis (LNM). This retrospective cohort study included 373 patients with T1 CRC who underwent ER + ASR or PS between January 2010 and December 2020 at a tertiary center in Taiwan. Surgical and oncological outcomes, including recurrence rates, LNM, 5-year overall survival (OS), and 5-year recurrence-free survival (RFS) were compared. Univariate and multivariate analyses identified risk factors for LNM. No significant differences were observed between the ER + ASR and PS groups in surgical outcomes, recurrence rates, LNM, 5-year OS (93% vs. 89%, P = 0.18), or 5-year RFS (89% vs. 88%, P = 0.47). Patients with ≥ 2 high-risk factors had significantly lower 5-year OS and RFS compared to those with ≤ 1 risk factor (p < 0.01). Poor histology grade and lymphovascular invasion were independent risk factors for LNM. ER + ASR and PS had comparable long-term outcomes in patients with T1 CRC. A multidisciplinary approach and standardized protocols are required for optimal management of early-stage CRC.
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