Evidence map›Paper›PMID 39833151›Full record

ArticleNature communications2025

Sleeve gastrectomy reveals the plasticity of the human gastric epithelium.

Amit Elad, Botros Moalem, Dana Sender, Aya Bardugo, Ki-Suk Kim, Yhara Arad, Haya Benhayon, Ayelet Gal Etzyoni, Nehemia Greenstein, Aviv Halfon and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Mesenchymal R-spondin 3 promotes an immunogenic tumor microenvironment with adaptive immune resistance in human gastric adenocarcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Amit Elad *Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0009-0003-5476-2529
Botros Moalem *Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Dana SenderDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Aya BardugoDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ki-Suk KimDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Yhara AradDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Haya BenhayonDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ayelet Gal EtzyoniDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0009-0002-0165-0112
Nehemia GreensteinDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Aviv HalfonDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Sarah KnappDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Michelle MalisDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Bailey PeckDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Itia SamuelDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Amram KupietzkyDepartment of Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0001-8624-4492
Saleh DaherInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Esther ForkoshInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
David HakimianInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Tiberiu HershcoviciInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Nadav IlaniInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Lior KatzInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Moshe RottenstreichInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Elez VainerInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Yuval IshayInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Eitan ZlotnickInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Abed NasereddinGenomics Applications Laboratory, Core Research Facility, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0001-8162-420X
Idid ShiffGenomics Applications Laboratory, Core Research Facility, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0001-5623-1017
Ariel BensonInstitute of Gastroenterology and Liver Disease, Hadassah University Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Ronit GrinbaumDepartment of Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Siddhartha MishraSeminar for Applied Mathematics, ETH, Zurich, Switzerland.
Shlomi KotlerThe Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-0191-5777
Linda C SamuelsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0898-2243
Darleen A SandovalDepartment of Pediatrics, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-3669-3278
Rachel Ben-Haroush SchyrDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Danny Ben-ZviDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. danny.ben-zvi@mail.huji.ac.il.ORCID http://orcid.org/0000-0002-8697-9744

Funding

Multidisciplinary Training Program in Basic Diabetes ResearchT32DK101357 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETER ARVAN, Ormond A MacDougald · 2014 to 2026
$4.1M
Mechanisms of Post-Bariatric HypoglycemiaR01DK121995 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PATTI, MARY E, SANDOVAL, DARLEEN A. · 2019 to 2022
$2.8M
Regulation of Gastric Epithelial Cells in the MouseR01DK056882 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMUELSON, LINDA C. · 2001 to 2011
$2.6M
Wnt Pathway Regulation of Gastric Stem Cell FunctionR01DK126451 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMUELSON, LINDA C. · 2022 to 2025
$2.0M
The role of enteroendocrine cell differentiation in the success of bariatric surgeryK01DK129367 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KIM, KI SUK · 2021 to 2025
$672k
Training for minoritized individuals in gut-brain axis researchK26DK138368 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DARLEEN A. SANDOVAL · 2023 to 2026
$461k
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 803526Israel Science Foundation (ISF) 0395062NIDDK NIH HHS K01 DK129367NIDDK NIH HHS K26 DK138368NIDDK NIH HHS R01 DK056882NIDDK NIH HHS R01 DK121995NIDDK NIH HHS R01 DK126451NIDDK NIH HHS T32 DK101357
6 · The paper itself

Abstract

Gastrin is secreted following a rise in gastric pH, leading to gastric acid secretion. Sleeve gastrectomy (SG), a bariatric surgery where 80% of the gastric corpus is excised, presents a challenge for gastric pH homeostasis. Using histology, and single-cell RNA sequencing of the gastric epithelium in 12 women, we observed that SG is associated with an increase in a sub-population of acid-secreting parietal cells that overexpress respiratory enzymes and an increase in histamine-secreting enterochromaffin-like cells (ECLs). ECLs of SG-operated patients overexpressed genes coding for biosynthesis of neuropeptides and serotonin. Mathematical modeling showed that pH homeostasis by gastrin is analogous to non-linear proportional and integral control, that drives adaptation of the epithelium to acid-secretion demand. Quantitative model predictions were validated in patients. The results demonstrate human gastric epithelium remodeling following SG at the molecular and cellular levels, and more generally how trophic hormones enable robust adaptation of tissue function to meet physiological demand.

Indexed as

GastrectomyGastric MucosaAdultEnterochromaffin-like CellsFemaleGastric AcidGastrinsHistamineHomeostasisHumansHydrogen-Ion ConcentrationMiddle AgedParietal Cells, GastricSerotoninSingle-Cell AnalysisGastrinsHistamineSerotonin

Identifiers

PMID39833151
PMCPMC11747362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.