Observational studyBMJ open2025
Association of quality of life in older patients with breast cancer: a cross-sectional study from China.
Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Impact of radiotherapy on quality of life reported by elderly patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to investigate the quality of life (QoL) of older Chinese patients with breast cancer and to explore further the associations of functions, symptoms, financial burdens and comorbidities with global health/quality of life (gQoL).
designThis was a cross-sectional study carried out following the Strengthening the Reporting of Observational Studies in Epidemiology checklist.
settingThis study was conducted in two hospitals in Beijing from October 2021 to November 2022.
participantsPatients with breast cancer aged over 65 years were included in the final analysis, which comprised a total of 481 patients. PRIMARY AND SECONDARY OUTCOME MEASURES: The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the Charlson Comorbidity Index (CCI) were used to assess patients' QoL and comorbidities. The data were analysed using network analysis and path analysis.
resultsOut of the 136 possible edges in the final networks, 84 (61.8%) were non-zero. 'Fatigue' was the central symptom and indirectly decreased the gQoL, which was mediated by increasing 'financial difficulties', 'CCI' and 'role function' (β = -0.35, p<0.001). 'Physical function' was also an important and direct intervention node that was indirectly related to gQoL, and this was mediated by 'role function' (β = -0.15, p=0.006). Path analysis accounted for 32.0% of the total effect.
conclusionsThe various dimensions of QoL are highly interrelated and mutually reinforcing. These results highlight the importance of improving the fatigue and physical function of older patients with breast cancer. Interventions targeting these symptoms may lead to an overall improvement in gQoL. TRIAL REGISTRATION NUMBER: ChiCTR2200056070; Public title: Frailty and Comorbidity in the Elderly Study (FACE Study).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.