Evidence map›Paper›PMID 39832890›Full record

ArticleBMJ open respiratory research2025

Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study.

Daniel-Costin Marinescu, Alyson W Wong, Aditi Shah, Cameron J Hague, Darra Murphy, Julia Yang, James Johnston, Janice Leung, Christopher Carlsten, Christopher J Ryerson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel-Costin MarinescuDivision of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada daniel.marinescu@vch.ca.ORCID http://orcid.org/0000-0003-3358-7699
Alyson W WongDivision of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Aditi ShahDivision of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Cameron J HagueDepartment of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
Darra MurphyDepartment of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
Julia YangCentre for Heart Lung Innovation, Vancouver, British Columbia, Canada.
James JohnstonDivision of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Janice LeungDivision of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Christopher CarlstenDivision of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Christopher J RyersonDivision of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPersistent lung abnormalities following COVID-19 infection are common. Similar parenchymal changes are observed in idiopathic pulmonary fibrosis (IPF). We investigated whether common genetic risk factors in IPF are associated with developing lung parenchymal abnormalities following severe COVID-19 disease.

methodsConsecutive adults hospitalised for laboratory-confirmed COVID-19 infection were prospectively recruited from March to May 2020. Three single-nucleotide polymorphisms (SNPs) conferring risk for IPF were genotyped (

results71 patients were included. Mean age was 63±16 years, 62% were male, 31% were ever-smokers and median hospital length of stay was 9±11 days, with 23% requiring mechanical ventilation. The

conclusionIn an adjusted analysis controlling for severity of infection,

Indexed as

COVID-19Idiopathic Pulmonary FibrosisLungMucin-5BAgedDipeptidyl-Peptidases and Tripeptidyl-PeptidasesFemaleGenetic LociGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotideProspective StudiesRespiratory Function TestsRisk FactorsDipeptidyl-Peptidases and Tripeptidyl-PeptidasesMUC5B protein, humanMucin-5BCOVID-19Idiopathic Pulmonary Fibrosis

Identifiers

PMID39832890
PMCPMC11752054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.