Observational studyArchives of disease in childhood. Fetal and neonatal edition2025
Plasma transfusions in neonatal intensive care units: a prospective observational study.
Observational study in Archives of disease in childhood. Fetal and neonatal edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- The specifications of blood components for neonatal transfusion: a European study and critical review.Pediatric research · 2026Article
- Plasma transfusion in neonatal sepsis.World journal of pediatrics : WJP · 2026Article
- Cord blood red cell concentrates for preterm neonate transfusion: Insights from the multicenter BORN trial.Transfusion · 2026Article
- Blood loss due to diagnostic testing in extremely preterm infants in 22 European countries: a prospective observational study.EClinicalMedicine · 2026Article
- Management of neonatal massive hemorrhage: A narrative review.Transfusion · 2026Review
- Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature.Acta anaesthesiologica Scandinavica · 2026Review
- Effect of fresh-frozen plasma transfusion on intraventricular hemorrhage risk in preterm infants with prolonged APTT: a target trial emulation with causal forest analysis.Frontiers in neuroscience · 2026Article
- The whole is greater than the sum of its parts: Rethinking our approach to neonatal transfusion research.Transfusion · 2025Review
Corrections and comments
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Authors and funding
33 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDespite lack of evidence supporting efficacy, prophylactic fresh frozen plasma and Octaplas transfusions may be administered to very preterm infants to reduce bleeding risk. International variation in plasma transfusion practices in neonatal intensive care units (NICUs) is poorly understood, therefore, we aimed to describe neonatal plasma transfusion practice in Europe.
designProspective observational study.
setting64 NICUs in 22 European countries, with a 6-week study period per centre between September 2022 and August 2023. PATIENTS: Preterm infants born below 32 weeks of gestational age.
interventionsAdmission to the NICU.
main outcome measuresPlasma transfusion prevalence, cumulative incidence, indications, transfusion volumes and infusion rates and adverse effects.
resultsA total of 92 of 1143 infants included (8.0%) received plasma during the study period, collectively receiving 177 transfusions. Overall prevalence was 0.3 plasma transfusion days per 100 admission days, and rates varied substantially across Europe. By day 28 of life, 13.5% (95% CI 10.0% to 16.9%) of infants received at least one plasma transfusion, accounted for competing risks of death or discharge. Transfusions were given for a broad range of indications, including active bleeding (29.4%), abnormal coagulation screen results (23.7%) and volume replacement/hypotension (21.5%). Transfusion volumes and infusion rates varied significantly; the most common volume was 15 mL/kg (range: 5-30 mL/kg) and the most common duration was 2 hours (range: 30 min to 6 hours).
conclusionsWe found wide variation in plasma transfusion practices in Europe, highlighting the need for evidence to inform neonatologists in daily practice and guidelines, in particular for non-bleeding indications. TRIAL REGISTRATION NUMBER: ISRCTN17267090.
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