Trial reportArchives of disease in childhood. Fetal and neonatal edition2025
Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- EBNEO Commentary: Permissive Hypotension in Preterm Infants-Is Masterly Inactivity the Right Approach?Acta paediatrica (Oslo, Norway : 1992) · 2026Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine survival and neurodevelopmental outcomes in the Hypotension in Preterm (HIP) trial.
designProspective follow-up of infants enrolled in randomised controlled trial.
participants58 infants born before 28 weeks of gestation with low mean arterial blood pressure.
interventionRandom allocation to treatment of low blood pressure values with infusion of dopamine or placebo. PRIMARY OUTCOME: Survival without neurodevelopmental impairment to 24 months corrected age (CA).
resultsThe HIP trial stopped early due to logistic and recruitment difficulties. Outcomes were determined for 55 infants (27 in the dopamine group and 28 in the placebo group) at 24 months CA. Survival without impairment was present in 13 (48%) infants in the dopamine group and 7 (25%) infants in the placebo group (OR 2.79 (95% CI 0.89, 8.72); p=0.078). The components of the primary outcome were similarly distributed between the two arms. Mean Bayley composite scores and the frequency of somatic impairments did not differ significantly between groups but infants were shorter and lighter at 2 years of age after dopamine administration.
conclusionIn this placebo-controlled trial of the treatment of hypotension in extremely preterm infants, dopamine administration did not increase survival without impairment at 2 years CA. However, the study was not sufficiently powered and a clinically important effect cannot be excluded. The role of inotropic medication in facilitating good outcomes requires further study.
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