Evidence map›Paper›PMID 39832791›Full record

ArticleACS biomaterials science & engineering2025

Modern Approach to Testing the Biocompatibility of Osteochondral Scaffolds in Accordance with the 3Rs Principle─Preclinical

Katarzyna Klimek, Sylwia Terpilowska, Agnieszka Michalak, Rafal Bernacki, Aleksandra Nurzynska, Magali Cucchiarini, Marta Tarczynska, Krzysztof Gaweda, Stanisław Głuszek, Grazyna Ginalska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katarzyna KlimekChair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.ORCID 0000-0003-4236-9087
Sylwia TerpilowskaDepartment of Surgical Medicine with the Laboratory of Medical Genetics, Jan Kochanowski University, Collegium Medicum, IX Wiekow Kielc 19A Av., 25-317 Kielce, Poland.
Agnieszka MichalakIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Chodzki 4a Street, 20-093 Lublin, Poland.
Rafal BernackiVeterinary Clinic Aura, Debowa 31 Street, 86-065 Lochowo, Poland.
Aleksandra NurzynskaChair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.
Magali CucchiariniCenter of Experimental Orthopaedics, Saarland University Medical Center, Saarland University, Kirrbergerstr. Bldg 37, 66421 Homburg/Saar, Germany.ORCID 0000-0003-0323-8922
Marta TarczynskaDepartment and Clinic of Orthopaedics and Traumatology, Medical University of Lublin, Jaczewskiego 8 Street, 20-954 Lublin, Poland.
Krzysztof GawedaDepartment and Clinic of Orthopaedics and Traumatology, Medical University of Lublin, Jaczewskiego 8 Street, 20-954 Lublin, Poland.
Stanisław GłuszekDepartment of Surgical Medicine with the Laboratory of Medical Genetics, Jan Kochanowski University, Collegium Medicum, IX Wiekow Kielc 19A Av., 25-317 Kielce, Poland.
Grazyna GinalskaChair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work is to provide a comprehensive set of biological tests to assess the biomedical potential of novel osteochondral scaffolds with methods proposed to comply with the 3Rs principle, focusing here on a biphasic Curdlan-based osteochondral scaffold as a promising model biomaterial.

Indexed as

beta-GlucansBiocompatible MaterialsMaterials TestingTissue ScaffoldsAnimalsCell ProliferationCell SurvivalChondrocytesDogsHumansOsteoblastsZebrafishbeta-GlucansBiocompatible Materialscurdlanbiocompatibility in vivocytocompatibility in vitrocytotoxicitygenotoxicityinflammationosteochondral scaffolds

Identifiers

PMID39832791
PMCPMC11815629

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.