ArticleChest2025
Characterization of Occupational Endotoxin-Related Small Airway Disease With Longitudinal Paired Inspiratory/Expiratory CT Scans.
Article in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model.The Journal of pharmacology and experimental therapeutics · 2026Article
- Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundAlthough small airway disease (SAD) has been recognized as a major contributor to obstructive respiratory diseases, the association between occupational endotoxin exposure and SAD, as characterized by CT scans, requires further investigation. RESEARCH QUESTION: What is the association between occupational endotoxin exposure and SAD, and which CT imaging biomarkers effectively detect preclinical airway dysfunction? STUDY DESIGN AND
methodsThis study included 404 patients from the Shanghai Textile Workers Cohort. We collected longitudinal inspiratory/expiratory CT scans, spirometry data, and endotoxin levels in 2011 and 2016. We evaluated the marginal association among endotoxin, small airway measures, and spirometry by Pearson correlation coefficient. We applied linear mixed models and linear regression models to understand the adjusted association among endotoxin, small airway measures, and spirometry.
resultsWe found significant association between endotoxin and SAD and airflow obstruction, as quantified by small airway measures and spirometry, respectively. All small airway measures were marginally correlated with endotoxin, among which relative volume change in voxels with attenuation between -856 Hounsfield units (HU) and -950 HU (RVC
interpretationWe found that occupational endotoxin exposure was significantly associated with SAD and lower FEV
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