Evidence map›Paper›PMID 39832532›Full record

ArticleContemporary clinical trials2025

Changes in weight and physical function for older African American women in Take Off Pounds Sensibly (TOPS): Study protocol for a randomized clinical trial.

Nia S Mitchell, Rebecca North, Anna Hung, Kathryn N Porter Starr, Connie W Bales, Cynthia J Coffman

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nia S MitchellDepartment of Medicine, Duke University School of Medicine, Durham, NC, USA. Electronic address: nia.s.mitchell@duke.edu.
Rebecca NorthDuke Center for Aging and Human Development, Duke University School of Medicine, Durham, NC, USA. Electronic address: rebecca.north13@duke.edu.
Anna HungDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA; Duke-Margolis Institute for Health Policy, Durham, NC, USA; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Medical Center, Durham, NC, USA. Electronic address: anna.hung@duke.edu.
Kathryn N Porter StarrDepartment of Medicine, Duke University School of Medicine, Durham, NC, USA; Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA. Electronic address: kathryn.starr@duke.edu.
Connie W BalesGeriatric Research, Education, and Clinical Center, Durham VA Medical Center, Durham, NC, USA. Electronic address: connie.bales@duke.edu.
Cynthia J CoffmanDepartment of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, USA; ADAPT Center of Innovation, Durham VA Health Care System, Durham, NC, USA. Electronic address: cynthia.coffman@duke.edu.

Funding

Supplement for Changes in Weight and Physical Function for Older African American Women in National, Peer-Led, Community-Based Weight Loss ProgramR01AG058725 · NIA · DUKE UNIVERSITY · PI MITCHELL, NIA SCHWANN · 2019 to 2024
$2.7M
NIA NIH HHS R01 AG058725
6 · The paper itself

Abstract

backgroundObesity and frailty are positively linked. Compared to other groups, older African American women have the highest rates of both obesity and frailty. Several academic weight loss interventions have shown that older adults can lose weight and improve physical function through diet and exercise. However, these programs do not have infrastructure for dissemination. Take Off Pounds Sensibly (TOPS) is a peer-led, community-based weight loss program with TOPS has a nationwide infrastructure that facilitates dissemination. Retrospective analyses showed that TOPS participants could lose a clinically significant amount of weight and maintain the loss for up to 7 years. This study will evaluate how TOPS participation affects weight change; physical function; cardiovascular disease risk factors; quality of life; and healthcare utilization among older African American women.

methodsWe are recruiting 104 older African American women aged ≥55 years with a BMI ≥ 27 kg/m DISCUSSION: If successful, this study will show that the TOPS program would be an option to treat excess weight and poor physical function among older African American women.

Indexed as

Black or African AmericanObesityWeight LossWeight Reduction ProgramsAgedBody Mass IndexCardiovascular DiseasesExerciseFemaleFrailtyHumansMiddle AgedQuality of LifeRandomized Controlled Trials as TopicRisk FactorsAfrican AmericanOlderPhysical functionWeight managementWomen

Identifiers

PMID39832532
PMCPMC12220930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.