ArticleIrish journal of medical science2025
Utility of systemic staging in breast cancer patients with a positive sentinel lymph node biopsy.
Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCT thorax, abdomen and pelvis (CT-TAP) remains the standard in the identification of metastatic disease in patients with newly diagnosed breast cancer. In patients with proven micro and macro axillary nodal metastasis, the optimal radiological technique remains controversial. A consensus on which patients with axillary nodal disease should receive radiological staging for distant disease and how this should be performed is not currently available. The aim of this study was to evaluate the yield from CT staging of the thorax, abdomen and pelvis (CT-TAP) in patients with proven nodal disease.
methodsPatients diagnosed with invasive breast cancer with a positive sentinel lymph node biopsy (SLNB) and subsequent staging CT-TAP between 2013 and 2017 were identified. Patient demographics, clinicopathological characteristics, CT-TAP findings and further imaging requirements were documented.
resultsA total of 234 patients were identified. Of these, 164 (70%) were found to have macrometastasis and 70 (30%) to have micrometastasis or isolated tumour cells on SLNB. Within the macrometastasis cohort, abnormalities were noted on staging CT-TAP for 100 (61%) patients. Eighty of the 100 received follow-up assessment of abnormalities with 3 (2%) patients being diagnosed with distant metastatic disease. Within the micrometastasis group, abnormalities on CT-TAP staging were noted in 36 (52.1%) patients. Twenty-eight (40%) patients required further investigation and follow-up. No patient was found to have metastatic disease within this group.
conclusionPatients diagnosed with micrometastatic disease of the axilla following a sentinel lymph node biopsy do not require systemic staging as it fails to detect metastatic disease.
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