Evidence map›Paper›PMID 39832085›Full record

ArticleMolecular diversity2025

Coumarin derivatives containing the 1,3,4 oxadiazole/thiadiazole moiety discovered as potential anti-tobacco mosaic virus agents.

Yuzhi Hu, Zhiling Sun, Wei Zeng, Yujiao Qiu, Zhiyuan Xu, Jing Zhang, Gang Feng

Abstract read
In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuzhi HuState Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Zhiling SunState Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Wei ZengState Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Yujiao QiuState Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Zhiyuan XuEnvironment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science, Haikou, 571101, China.
Jing ZhangEnvironment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science, Haikou, 571101, China. zh-jing99@163.com.
Gang FengEnvironment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science, Haikou, 571101, China. feng8513@sina.com.

Funding

Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences 1630042024020Chinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science Center CATASCXTD202410the Key Research Development Program of Hainan Province, China ZDYF2024XDNY202the National Natural Science Foundation of China 32372598
6 · The paper itself

Abstract

In this paper, a series of oxadiazole/thidiazole containing coumarin derivative derivatives were designed, synthesized and characterized using NMR and HRMS. The evaluation of antiviral activity revealed that some of the synthesized compounds exhibited good in vivo antiviral efficacy against tobacco mosaic virus (TMV). Notably, compounds H6 and Y5 demonstrated exceptional therapeutic and protective effects against TMV, with EC

Indexed as

Antiviral AgentsCoumarinsOxadiazolesThiadiazolesTobacco Mosaic VirusCapsid ProteinsNicotianaPlant LeavesStructure-Activity RelationshipSuperoxide Dismutase1,3,4-oxadiazole1,3,4-thiadiazoleAntiviral AgentsCapsid ProteinsCoumarinsOxadiazolesSuperoxide DismutaseThiadiazolesAntiviral activityCoumarinOxadiazoleThiadiazole

Identifiers

PMID39832085
PMCPMC12638418

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.