Evidence map›Paper›PMID 39832078›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Cianidanol from Sea Buckthorn Exert Anti-Inflammatory Effects by the Inhibiting JAK2/STAT3 Signaling Pathway via an Integrative Pharmacology Strategy.

Chuan Liu, Xiangrui Yi, Yafan Li, Huijuan Xu, Peng Wang, Wenyu Yang, Ling Li, Ya Tu

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chuan LiuSchool of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Xihua University, Chengdu, 610039, China. 1220210030@mail.xhu.edu.
Xiangrui YiSchool of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Xihua University, Chengdu, 610039, China.
Yafan LiSchool of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Xihua University, Chengdu, 610039, China.
Huijuan XuSchool of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Xihua University, Chengdu, 610039, China.
Peng WangSchool of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Xihua University, Chengdu, 610039, China.
Wenyu YangSchool of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Xihua University, Chengdu, 610039, China.
Ling LiSchool of Comprehensive Health Management, Xihua University, Chengdu, 610039, China.
Ya TuExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Tuya126@126.com.

Funding

National Natural Science Foundation of China 82274212Talent Introduction Project of Xihua University Z211066Young Scientists Fund of National Natural Science Foundation of China 82204764
6 · The paper itself

Abstract

Sea buckthorn is a model of medicine and food homology, but the chemical composition and mechanism of anti-inflammatory effects are limited. In this study, the key components and mechanisms of the anti-inflammatory effects of sea buckthorn were identified based on UPLC-Q-TOF-MS, network pharmacology, molecular docking, molecular dynamics and RAW264.7 cells. The predicted key anti-inflammatory compounds in sea buckthorns were cianidanol, kaempferol, pelargonidin, and ent-epicatechin, and the key targets were EGFR, TNF, STAT3, and IL-10. The anti-inflammatory effects of sea buckthorn may be achieved via the synergistic regulation of multiple biological pathways. Furthermore, cianidanol significantly reduced the secretion of NO, IL-6, TNF-α, and IL-1β and the expression of phosphorylated JAK2 and STAT3 in LPS-stimulated RAW264.7 cells, as determined by ELISA and western blotting. Cianidanol from sea buckthorns exerts anti-inflammatory effects by reducing the expression of inflammatory mediators and pro-inflammatory cytokines, and inhibiting the JAK2/STAT3 signaling pathway. Thus, sea buckthorn can be developed into a promising functional food with anti-inflammatory properties.

Indexed as

Anti-Inflammatory AgentsHippophaeJanus Kinase 2Signal TransductionSTAT3 Transcription FactorAnimalsAnthocyaninsCytokinesKaempferolsMiceMolecular Docking SimulationNetwork PharmacologyRAW 264.7 CellsAnthocyaninsAnti-Inflammatory AgentsCytokinesJak2 protein, mouseJanus Kinase 2KaempferolsStat3 protein, mouseSTAT3 Transcription FactorAnti-inflammatoryCianidanolJAK2/STAT3 signaling pathwaySea buckthorn

Identifiers

PMID39832078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.