Evidence map›Paper›PMID 39832031›Full record

ReviewNeurochemical research2025

Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies.

Akshata Choudhari Padti, Santosh Mallikarjun Bhavi, Bothe Thokchom, Sapam Riches Singh, Shivanand S Bhat, B P Harini, Mika Sillanpää, Ramesh Babu Yarajarla

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akshata Choudhari PadtiDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.ORCID http://orcid.org/0009-0000-2411-0931
Santosh Mallikarjun BhaviDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.ORCID http://orcid.org/0000-0001-6813-8952
Bothe ThokchomDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.ORCID http://orcid.org/0000-0001-5659-5320
Sapam Riches SinghDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India.ORCID http://orcid.org/0009-0004-1468-464X
Shivanand S BhatDepartment of Botany, Smt. Indira Gandhi Government First Grade Women's College, Sagar, Karnataka, 577401, India.ORCID http://orcid.org/0009-0001-2388-6954
B P HariniDepartment of Zoology and Centre for Applied Genetics, Bangalore University, Bangaluru, Karnataka, 560056, India.ORCID http://orcid.org/0000-0001-7054-7675
Mika SillanpääDepartment of Biological and Chemical Engineering, Aarhus University, Norrebrogade 44, Aarhus C, 8000, Denmark.
Ramesh Babu YarajarlaDrosophila and Nanoscience Research Laboratory, Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, 580003, India. rameshy@kud.ac.in.ORCID http://orcid.org/0000-0002-1325-059X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review explores the intricate connections between Drosophila models and the human blood-brain barrier (BBB) with nanoparticle-based approaches for neurological treatment. Drosophila serves as a powerful model organism due to its evolutionary conservation of key biological processes, particularly in the context of the BBB, which is formed by glial cells that share structural and functional similarities with mammalian endothelial cells. Recent advancements in nanoparticle technology have highlighted their potential for effective drug delivery across the BBB, utilizing mechanisms such as passive diffusion, receptor-mediated transcytosis, and carrier-mediated transport. The ability to engineer nanoparticles with specific physicochemical properties-such as size, surface charge, and functionalization-enhances their targeting capabilities, particularly towards astrocytes, which play a crucial role in maintaining BBB integrity and responding to neuroinflammation. Insights gained from Drosophila studies have informed the design of personalized nanomedicine strategies aimed at treating neurodegenerative diseases, including Alzheimer's, Parkinson's disease etc. As research progresses, the integration of findings from Drosophila models with emerging humanized BBB systems will pave the way for innovative therapeutic approaches that improve drug delivery and patient outcomes in neurological disorders.

Indexed as

AstrocytesBlood-Brain BarrierNanoparticlesAnimalsDrosophilaDrug Delivery SystemsHumansNeurodegenerative DiseasesAstrocytesBlood brain barrierCentral nervous systemDrosophilaGlial cellNanoparticles

Identifiers

PMID39832031

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.