Evidence map›Paper›PMID 39831977›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens.

Mona M Soliman, Ahmed H M Elwahy, Ahmed M Sayed, Mahmoud Ibrahim, Mohamed A Dawoud, Shahd Hisham Mohamed Ali, Menna Tallah S Nady, Nada A Hassan, Wessam Saad, Ismail A Abdelhamid

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  7. Review
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  9. IUCrData · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mona M SolimanDepartment of Botany and Microbiology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Ahmed H M ElwahyDepartment of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt. aelwahy@cu.edu.eg.
Ahmed M SayedDepartment of Botany and Microbiology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Mahmoud IbrahimDepartment of Botany and Microbiology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Mohamed A DawoudDepartment of Botany and Microbiology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Shahd Hisham Mohamed AliDepartment of Botany and Microbiology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Menna Tallah S NadyDepartment of Biotechnology, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt.
Nada A HassanDepartment of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Wessam SaadDepartment of Biotechnology, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt.
Ismail A AbdelhamidDepartment of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt. ismail_shafy@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Piperazine-based compounds have garnered significant attention due to their notable biological and pharmacological activities, making them essential in fine chemical and pharmaceutical applications. In this study, we managed to synthesize a novel hybrid bis-cyanoacrylamide bearing the piperazine core via phenoxymethyl linker and incorporating sulphamethoxazole moiety. The novel compound was fully characterized using different spectral data including 1H-NMR,

Indexed as

AcrylamidesAnti-Bacterial AgentsAnti-Infective AgentsArthritis, RheumatoidPiperazinesBacteriaFungiMicrobial Sensitivity TestsMolecular Docking SimulationStructure-Activity RelationshipAcrylamidesAnti-Bacterial AgentsAnti-Infective AgentsPiperazinesAntibacterial agentAntifungal agentBis-cyanoacrylamide-based-piperazineMolecular dockingRheumatoid arthritisSulphamethoxazole

Identifiers

PMID39831977
PMCPMC12263765

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.