Evidence map›Paper›PMID 39831841›Full record

ArticleJournal of neurotrauma2025

Prospective Harmonization, Common Data Elements, and Sharing Strategies for Multicenter Pre-Clinical Traumatic Brain Injury Research in the Translational Outcomes Project in Neurotrauma Consortium.

Ina-Beate Wanner, Joseph T McCabe, J Russell Huie, Neil G Harris, Afshin Paydar, Chloe McMann-Chapman, Anthony Tobar, Alexandru Korotcov, Mark P Burns, Raymond C Koehler and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Multi-site,Frontiers in neurology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ina-Beate WannerIntellectual and Developmental Disability Center (IDDRC), David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California, USA.ORCID 0000-0002-2814-1281
Joseph T McCabeDepartment of Anatomy, Physiology & Genetics, School of Medicine, Uniformed Services University, Bethesda, Maryland, USA.
J Russell HuieBrain and Spinal Injury Center (BASIC), Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, California, USA.ORCID 0000-0001-5594-4277
Neil G HarrisDepartment of Neurosurgery, Brain Research Injury Center (BIRC), Geffen School of Medicine, UCLA, Los Angeles, California, USA.ORCID 0000-0002-1965-6750
Afshin PaydarDepartment of Neurosurgery, Brain Research Injury Center (BIRC), Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Chloe McMann-ChapmanIntellectual and Developmental Disability Center (IDDRC), David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California, USA.
Anthony TobarSemel Institute for Neuroscience and Human Behavior, IDDRC, Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Alexandru KorotcovDepartment of Radiology & Radiological Sciences, Uniformed Services University, Bethesda, Maryland, USA.
Mark P BurnsGeorgetown University Medical Center, Center for Neural Injury and Repair, Washington, District of Columbia, USA.
Raymond C KoehlerDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jieru WanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Javier Allende LabastidaDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jonathan TongSemel Institute for Neuroscience and Human Behavior, IDDRC, Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Jinyuan ZhouDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.
Lex Maliga DavisBrain and Spinal Injury Center, University of California, San Francisco, California, USA.
Hannah L RadabaughBrain and Spinal Injury Center, University of California, San Francisco, California, USA.
Adam R FergusonBrain and Spinal Injury Center (BASIC), Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, California, USA.
Timothy E Van MeterCSO, BRAINBox Solutions, Richmond, Virginia, USA.
Marcelo FeboDepartmet Psychiatry, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-8981-4163
Prodip BoseDepartment of Anesthesiology, and Department of Neurology at the College of Medicine, University of Florida, Gainesville, Florida, USA.
Kevin K WangDepartment of Neurobiology, Center for Neurotrauma, Multiomics & Biomarkers, Morehouse School of Medicine, Atlanta, Georgia, USA.
Firas KobeissyDepartment of Neurobiology, Center for Neurotrauma, Multiomics & Biomarkers, Morehouse School of Medicine, Atlanta, Georgia, USA.
Seza ApiliogullariDepartment of Neurobiology, Center for Neurotrauma, Multiomics & Biomarkers, Morehouse School of Medicine, Atlanta, Georgia, USA.
Jiepei ZhuDepartment of Neurobiology, Center for Neurotrauma, Multiomics & Biomarkers, Morehouse School of Medicine, Atlanta, Georgia, USA.
Richard RubensteinDepartment of Neurology, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.ORCID 0000-0003-0577-6687
Hibah O AwwadDivision of Neuroscience, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
TOP-NT Consortium Investigators

Funding

Tools for Common Data Element Adoption in the Pan-Neurotrauma Data Commons (PANORAUMA)U24NS122732 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADAM R FERGUSON, Jeffrey S. Grethe · 2021 to 2026
$5.0M
Predictive Accuracy of Acute Astroglial Compromise Biomarkers after Traumatic Brain InjuryUH3NS106945 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARRIS, NEIL, WANNER, INA BEATE · 2020 to 2023
$1.4M
Development of Novel Functional Markers for TBI Using Molecular MRIUH3NS106937 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES, ZHOU, JINYUAN · 2020 to 2022
$1.3M
Detecting the disruption and recovery of synaptic connectivity after TBIUH3NS106941 · NINDS · GEORGETOWN UNIVERSITY · PI BURNS, MARK P · 2020 to 2022
$1.2M
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)UH3NS106899 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2020 to 2022
$1.2M
Predictive accuracy of acute astroglial compromise biomarkers after traumatic brain injuryUG3NS106945 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARRIS, NEIL, WANNER, INA BEATE · 2018 to 2020
$882k
Development of Novel Functional Markers for TBI Using Molecular MRIUG3NS106937 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES, ZHOU, JINYUAN · 2018 to 2019
$859k
NINDS NIH HHS U24 NS122732NINDS NIH HHS UG3 NS106937NINDS NIH HHS UG3 NS106945NINDS NIH HHS UH3 NS106899NINDS NIH HHS UH3 NS106937NINDS NIH HHS UH3 NS106941NINDS NIH HHS UH3 NS106945
6 · The paper itself

Abstract

Effective team science requires procedural harmonization for rigor and reproducibility. Multicenter studies across experimental modalities (domains) can help accelerate translation. The Translational Outcomes Project in NeuroTrauma (TOP-NT) is a pre-clinical traumatic brain injury (TBI) consortium charged with establishing and validating noninvasive TBI assessment tools through team science. Here, we present practical approaches for harmonization of TBI research across five centers providing needed vocabulary and structure to achieve centralized data organization and use. This includes data sharing as an essential step that enables validating data between domains, evaluating reproducibility between sites, and performing multimodal analyses. As part of this process, TOP-NT (1) produced a library of TBI-relevant standard operating procedures to coordinate workflow, (2) aligned 481 pre-clinical and clinical common data elements (CDEs), and (3) generated 272 new pre-clinical TBI CDEs. This consortium then (4) connected diverse data types to validate assessments across domains and to allow multivariable TBI phenotyping. Lastly, TOP-NT (5) specified technical quality controls for pre-clinical studies. These harmonization tools can facilitate reproducibility in team science, help distinguish a wide injury spectrum from technical variability, apply quality-controls, and ease higher level data analyses. TOP-NT uses three rat TBI models across four sites. Each site collects primary outcome measures, including magnetic resonance imaging (MRI) protocols and blood biomarkers of neuronal and glial injury, validated by histopathology and behavioral outcomes. Collected data are organized using the 481 TOP-NT pre-clinical CDEs, covering surgical, behavioral, biomarker, MRI, and quantitative histopathological methods. We report data curation steps suited for data storage using the Open Data Commons for TBI as a centralized data repository, allowing unbiased cross-site analysis. This approach leads to introducing a higher level, syndromic understanding of TBI signatures. TOP-NT authors outline a semantic and structural framework suggesting strategies for robust pre-clinical research in multicenter trials to improve translatability for TBI assessments. [Figure: see text].

Indexed as

Brain Injuries, TraumaticCommon Data ElementsInformation DisseminationMulticenter Studies as TopicTranslational Research, BiomedicalAnimalsHumansProspective StudiesReproducibility of ResultsBidirectional translationData organizing logisticsInternal and external validityMultimodal TBI phenotypesMulti-site preclinical trial collaborationNoninvasive diagnostic assessmentsUnified interoperable vocabulary

Identifiers

PMID39831841
PMCPMC12174484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.