SynthesisActa paediatrica (Oslo, Norway : 1992)2026
Respiratory Syncytial Virus Vaccination Is Associated With Increased Odds of Preterm Birth.
Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Respiratory Syncytial Virus Vaccination Is Associated With Increased Odds of Preterm Birth.Acta paediatrica (Oslo, Norway : 1992) · 2026Pooled it
- RSV-Pre-F Vaccination During Pregnancy and Neonatal Outcomes-A Systematic Review and Meta-Analysis.Immunity, inflammation and disease · 2026Pooled it
- Efficacy and safety of maternal RSV vaccination against infant lower respiratory tract infections: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Maternal RSV vaccination: clinical efficacy, safety, and global policy considerations: a systematic review.Journal of pharmaceutical policy and practice · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
aimTo analyse whether respiratory syncytial virus (RSV) vaccination during pregnancy increases the odds of preterm birth.
methodsA rapid review and meta-analysis was performed. The main outcome was the risk of preterm (gestational week less than 37) birth. A fixed-effects model was used to analyse pooled odds ratios (OR) with 95% confidence intervals (CI). Evidence certainty was assessed according to GRADE.
resultsWe included six randomised controlled trials with 17 656 births and two observational studies with 3446 births. The odds for preterm birth were increased in the randomised studies (OR 1.17, CI 1.02-1.34). No evidence of a difference was seen in the observational studies (OR 0.93, CI 0.69-1.25). Combined, these showed increased odds for preterm birth (OR 1.13, CI 1.00-1.27). Evidence certainty was rated to be moderate. When restricted to market-approved vaccine, the odds seemed to be increased in RCTs (OR 1.21, CI 0.98-1.49).
conclusionBased on the available evidence, RSV vaccination seems to be associated with increased odds for preterm birth. RSV vaccination needs continuous population-level observational safety data monitoring on the perinatal outcomes during the early phases of vaccine rollouts to detect possible safety signals and further confirm the magnitude of the effect on preterm birth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.