ArticleMagnetic resonance in medicine2025
Composite spin probes with adjustable oxygen sensitivity for pulse electron paramagnetic resonance imaging.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Reconfigurable animal bed-EPR resonator assembly for multimodal co-registration.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Computationally efficient 4D spectral-spatial EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
purposeSolid crystalline spin probes, such as lithium phthalocyanine (LiPc) and lithium octa-n-butoxynaphthalocyanine (LiNc-BuO), allow repeated oxygen measurement using electron paramagnetic resonance (EPR). Due to their short relaxation times, their use for pulse EPR oxygen imaging is limited. In this study, we developed and tested a new class of solid composite spin probes that modified the relaxation rates R
methodsThe composite probes were developed by embedding LiPc or LiNc-BuO with bonewax, beeswax, or petroleum jelly. All experiments were performed using a 25-mT EPR imager, JIVA-25®. A selected composite probe, LiPc-BW5 (LiPc + 5-times bonewax), was tested for its in vivo stability and robustness using oxygen-enhanced EPR oxygen imaging. As another application, a LiPc-BW5-based marker was tested to outline the SCC7 tumor in a C3H mouse.
resultsThe composite probes showed an increased oxygen measurement range compared with unaltered probes. The in vivo experiments with LiPc-BW5 showed the stability of the probes for repeated oxygen imaging up to 4 weeks of measurements. The in vivo pO
conclusionsWe developed a new class of robust and versatile solid composite probes with adjustable oxygen sensitivity that allows pO
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