ArticleMagnetic resonance in medicine2025
The proton resonance enhancement for CEST imaging and shift exchange (PRECISE) family of RF pulse shapes for CEST MRI.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Brain Tumor Imaging with Iopamidol CEST MRI: In Vivo Detection and Validation.Chemical & biomedical imaging · 2026Article
- Generalization of Optimal Control Saturation Pulse Design for Robust and High CEST Contrast.Magnetic resonance in medicine · 2026Article
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Abstract
purposeTo optimize a 100 ms pulse for producing CEST MRI contrast and evaluate in mice.
methodsA gradient ascent algorithm was employed to generate a family of 100 point, 100 ms pulses for use in CEST pulse trains (proton resonance enhancement for CEST imaging and shift exchange). Gradient ascent optimizations were performed for exchange rates = 500, 1500, 2500, 3500, and 4500 s
resultsThe most promising pulse in terms of contrast performance across all three phantoms was the 9.6 ppm, 2500 s
conclusionA new 100-ms pulse was developed based on gradient ascent optimizations, which produced better contrast compared to standard Gaussian and Fermi pulses in phantoms. This shape also showed a substantial improvement for CEST MRI pH mapping in live mice over the Gaussian shape and appears promising for a wide range of CEST applications.
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