Evidence map›Paper›PMID 39831267›Full record

ArticleOpen medicine (Warsaw, Poland)2025

Antiangiogenic potential of

Nausheen Nazir, Arbaz Waqar, Amir Zaib Khan, Ayaz Ali Khan, Tariq Aziz, Abdullah F Alasmari

Abstract read
In one paragraph

Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nausheen NazirDepartment of Biochemistry, University of Malakand, Chakdara Dir Lower 18800, Pakistan.
Arbaz WaqarDepartment of Biochemistry, University of Malakand, Chakdara Dir Lower 18800, Pakistan.
Amir Zaib KhanDepartment of Biochemistry, University of Malakand, Chakdara Dir Lower 18800, Pakistan.
Ayaz Ali KhanDepartment of Biotechnology, University of Malakand, Chakdara Dir Lower 18800, Pakistan.
Tariq AzizLaboratory of Animal Health Food Hygiene and Quality, University of Ioannina, Arta, Greece.
Abdullah F AlasmariDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. Natural sources like plants are currently being explored for its antiangiogenic activity as they are factories of various phytochemicals. The goal of the current study is to investigate the antiangiogenic potential of Methods: Based on our previous research, the antiangiogenic activity was carried out using active fractions including crude methanol (Eu-Met), ethyl acetate (Eu-EtAc), and chloroform (Eu-Chf) extracts using CAM assay. Furthermore, to understand the binding mechanism of identified compounds, molecular docking was performed against vascular endothelial growth factor receptor 2 (VEGFR-2) using AutoDock vina as docking software. VEGFR-2 is overexpressed in pathological angiogenesis. Results: In CAM assay, Eu-Met, Eu-EtAc, and Eu-Chf extracts showed antiangiogenic activities but notable antiangiogenic activities were exhibited by Eu-Chf with IC Conclusion: Based on our results, we can claim that

Indexed as

antiangiogenic effectCAM assayElaeagnus umbellatamolecular docking

Identifiers

PMID39831267
PMCPMC11742088

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.