ArticleJournal of thoracic disease2024
A two-sample mendelian randomization study of non-tuberculous mycobacteria infection and lung cancer.
Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Background: Non-tuberculous mycobacterial lung disease may coexist or precede lung cancer, yet a causal link remains unproven. This study aimed to elucidate the causal association between non-tuberculous mycobacteria (NTM) and lung cancer. Methods: Summary data from genome-wide association studies (GWAS) for NTM, atypical mycobacterial lung infections, and various types of lung cancer were utilized. A two-sample Mendelian randomization (MR) design was applied using the inverse variance weighted (IVW), weighted median, weighted mode, and MR-Egger regression methods. Sensitivity analysis and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) were used to detect and correct for horizontal pleiotropy. The leave-one-out analysis was used to evaluate the robustness of the results. Results: The IVW results showed no significant causal relationships between NTM infection and the risk of lung cancer and between atypical mycobacterial lung infection and the risk of lung cancer. The results of the weighted median, weighted mode, and MR-Egger regression methods aligned with those of the IVW method. Cochran's Conclusions: The findings of this study do not support a genetically causal relationship between NTM and atypical mycobacterial lung infections with lung cancer.
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