ArticleJournal of thoracic disease2024
Specific risks and outcomes of octogenarians post-lung cancer resection: our 5-year experience.
Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Too Old for Surgery? A Case Report of an Octogenarian Patient With Locally Advanced Lung Cancer Achieving Long-Term Survival via Bilobectomy Followed by Adjuvant Targeted Therapy.Cancer reports (Hoboken, N.J.) · 2026Article
- Major Postoperative Complications and Survival After Lung Cancer Resection in Patients Aged ≥80 Years: Risk Factor Analysis.Current oncology (Toronto, Ont.) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: An increasingly large proportion of patients undergoing curative surgery for lung cancer, are octogenarians. We evaluated our short and long-term survival and adverse outcomes after oncological lung resections. Methods: Octogenarians undergoing anatomical resection for confirmed or suspected lung cancer at a single-centre between January 2016 and December 2021 were included. Retrospective analysis of demographic, clinical, and operative data was performed and correlated with mortality and long-term outcomes. Results: Out of 214 patients, 189 were included in the final analysis. Median age was 82 years (range, 80-89 years). Most patients had lobectomies and minimally invasive approach. Ninety-day mortality was 3.2% with no intraoperative deaths. Chronic obstructive pulmonary disease (COPD) primarily conferred a greater likelihood of persistent air leak (PAL), chest infection, reintubation and intensive care admission (all P<0.01). Complications occurred more in those with high white cell counts (WCCs) (P=0.03) and squamous cell carcinoma subtype (P<0.01). Wedge resections conferred fewer complications (P=0.049). Hospital length of stay (LOS) was reduced by 1 day in sublobar resections (P=0.01) and halved in minimally invasive approaches compared to thoracotomy (P=0.02). The median overall survival (OS) was 3.5 years (1-, 3-, and 5-year survival was 82.5%, 57.1%, and 38.2%, respectively). Pathological tumour stage (P<0.01) and incomplete resection (R1 or R2) (P=0.02) conferred a worse OS and disease-free survival (DFS). Median DFS was 2.4 years. No significant difference was seen in OS or DFS from extent of resection or tumour subtype (P=0.78, P=0.97 and P=0.40, P=0.91). Conclusions: Curative surgery is safe and feasible with good long-term outcomes in appropriately selected octogenarians. Predictors of specific complications can be identified and optimised in order to better counsel patients pre-operatively and offer surgery at an early pathological stage.
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