Evidence map›Paper›PMID 39831170›Full record

ArticleHeliyon2025

Phenotypic age mediates the associations between platelet-to-lymphocyte ratio and all-cause and cause-specific mortality: A prospective cohort study.

Xiangjun Li, Jia Wang, Mengqi Zhang, Yujing Li, Xiaoxuan Li, Jiaqi Zhang, Lihua Zhang, Yixuan Zhang, Zhenkang Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiangjun LiBreast Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jia WangDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Mengqi ZhangDepartment of Oncology, Key Laboratory of Cancer Molecular and Translational, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yujing LiDepartment of Pathology, The First Hospital of China Medical University, College of Basic Medical Sciences of China Medical University, Shenyang, Liaoning, China.
Xiaoxuan LiDepartment of Oncology, Key Laboratory of Cancer Molecular and Translational, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jiaqi ZhangDepartment of Medicine, Qingdao University, Qingdao, Liaoning, China.
Lihua ZhangDepartment of Medicine, Qingdao University, Qingdao, Liaoning, China.
Yixuan ZhangDepartment of Medicine, Qingdao University, Qingdao, Liaoning, China.
Zhenkang QiuInterventional Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The platelet-to-lymphocyte ratio (PLR) is a novel indicator of inflammation, but research on the links and mechanisms between the PLR and long-term health conditions is lacking. This study aimed to evaluate the relationship between phenotypic age (PhenoAge) mediated PLR and mortality among US adults. Methods: A total of 37,182 participants from the National Health and Nutrition Examination Survey (NHANES) database (1999-2018) were included to evaluate the PLR's relevance to survival by Cox regression models. The associations between the PLR and mortality were apparent using restricted cubic spline regression. Mediation analyses were conducted to investigate the mediated effects of PhenoAge on the associations of PLR with mortality. Results: Compared to the PLR in Quintile 1 participants, the multivariable-adjusted Cox model showed the PLR in Quintile 5 was linked with greater risks of death from all-cause ( Conclusion: The PLR, a valuable index that should be recommended for use, was independently linked with all-cause and cause-specific mortality, with PhenoAge playing a partial mediating role in the relationships.

Indexed as

All-cause mortalityCause-specific mortalityNHANESPhenotypic agePlatelet-to-lymphocyte ratio

Identifiers

PMID39831170
PMCPMC11742625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.