ArticleFrontiers in cellular and infection microbiology2024
Clinical efficacy of antibiotic-loaded bone cement and negative pressure wound therapy in multidrug-resistant organisms diabetic foot ulcers: a retrospective analysis.
Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- [Expert consensus on the application of bone cement in the treatment of diabetic wounds (2026 edition)].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Clinical outcomes of tibial cortex transverse transport versus antibiotic-loaded bone cement for Wagner grade 3-4 diabetic foot ulcers: a real-world retrospective cohort study.Frontiers in endocrinology · 2026Article
- A protonation/degradation dual control pH-responsive LVF delivery system with rod-shaped core-shell structure for the treatment of bone infections.Materials today. Bio · 2025Article
- Engineering macrophage phenotype switching via nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome inhibition: A translational approach using antibiotic cement for diabetic foot ulcers.Bioengineering & translational medicine · 2025Article
- Exo-hydrogel therapy: a revolutionary approach to managing diabetic complications.Journal of nanobiotechnology · 2025Review
- Role of nuclear factor erythroid 2-related factor 2 in negative pressure wound therapy for diabetic foot ulcers.World journal of diabetes · 2025Article
- Development and validation of a perioperative risk prediction model for pressure ulcers in neurosurgical procedures: a machine learning approach with protocol compliance metrics.Frontiers in medicine · 2025Article
- Consensus on the Diagnosis and Treatment of Adult Necrotizing Fasciitis (2025 Edition).Burns & trauma · 2025Article
- Application of composite layered repair system using titanium mesh, bone cement and vacuum sealing drainage for chest wall defect.Frontiers in medicine · 2025Article
- Comparative analysis of the therapeutic effect of antibiotic bone cement on Wagner grade 3 or 4 diabetic foot ulcer in heel and non-heel areas: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Sequential application of vacuum sealing drainage and antibiotic-loaded bone cement for the successful treatment of a diabetic ischemic foot ulcer: a case report.Frontiers in endocrinology · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
Objective: The purpose of this study was to investigate the clinical efficacy of antibiotic-loaded bone cement (ALBC) combined with Negative pressure wound therapy (NPWT) aspiration technique in the treatment of multidrug-resistant diabetic foot ulcers (MDRO-DFUs). Methods: A retrospective analysis of the clinical data of 80 patients with MDROs-DFU who were used Vacuum sealing drainage (VSD) as NPWT excipient and met the inclusion criteria from January 2019 to January 2024 at our hospital. Patients were divided into an experimental group and a control group, with 40 cases in each. The control group received conventional treatment, routine debridement, and NPWT treatment, while the experimental group received ALBC treatment in addition to the treatment plan of the control group. Measurements of blood inflammatory indicators, foot hemodynamic indicators, wound bacterial clearance time, wound healing time, and hospital stay were taken before and after treatment for both groups. Results: Inflammatory indexes, Vascular endothelial growth factor(VEGF), and internal diameter of dorsalis pedis arteriosus of both groups after treatment were significantly better than those before treatment, and the improvement of the experimental group was more obvious than that of the control group; the experimental group had a significantly shorter time of trauma bacterial turnover, healing time of trauma, and hospitalization time compared with that of the control group (P<0.05).
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