ArticleBrain hemorrhages2022
Confirming Subarachnoid Hemorrhage Induction in the Endovascular Puncture Mouse Model.
Article in Brain hemorrhages, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Platelets cause microvascular occlusion and delayed neurological deficits after subarachnoid hemorrhage in mice.Experimental & molecular medicine · 2026Article
- 12/15-Lipooxygenase Inhibition Reduces Microvessel Constriction and Microthrombi After Subarachnoid Hemorrhage in Mice.Translational stroke research · 2025Article
- Optimization and evaluation of an experimental subarachnoid hemorrhage model in mice.Scientific reports · 2025Article
- Toward Precision Modeling of Cough-Variant Asthma: Standardized Murine Models, Multidimensional Evaluation, and Translational Applications.Journal of asthma and allergy · 2025Review
- 12/15-Lipooxygenase Inhibition Reduces Microvessel Constriction and Microthrombi after Subarachnoid Hemorrhage in Mice.Research square · 2024Article
- Incidence and Factors in Delayed Neurological Deficits after Subarachnoid Hemorrhage in Mice.Brain hemorrhages · 2024Article
- Neutrophils and Neutrophil Extracellular Traps Cause Vascular Occlusion and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
Background and Purpose: Experimental studies of subarachnoid hemorrhage (SAH) using the endovascular perforation model routinely use either cerebral blood flow (CBF) or intracranial pressure (ICP) monitoring to confirm SAH induction. We designed this study to test the hypothesis that contralateral CBF is a better marker of SAH induction than ipsilateral CBF. Methods: Sixty-eight adult C57BL/6J mice were subjected to endovascular perforation. Mice were monitored using laser Doppler (for relative CBF) or ICP probes. Results: The ipsilateral CBF significantly decreased prior to ICP rising. However, reduction of the CBF in the contralateral hemisphere occurred at the same time as the rise in ICP. When CBF is monitored on both hemispheres simultaneously, the drop in ipsilateral CBF precedes the drop in the contralateral CBF. Conclusions: The most suitable method for confirming puncture and induction of SAH in the endovascular mouse model is by ICP. Monitoring the CBF of the contralateral hemisphere is also able to detect the moment of SAH induction. However, monitoring the ipsilateral CBF is not satisfactory for determining puncture and induction of SAH due to the changes in CBF caused by blood flow occlusion from the endovascular filament as it enters into the circle of Willis.
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